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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2026; 18(2): 115224
Published online Feb 15, 2026. doi: 10.4251/wjgo.v18.i2.115224
Published online Feb 15, 2026. doi: 10.4251/wjgo.v18.i2.115224
Relationship between preoperative modified frailty index, immune-inflammation index, and outcomes of colorectal cancer surgery in older patients
Xing-Si Qi, Nai-Ling Liu, Lin Yang, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Jing Xie, Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Author contributions: Qi XS and Yang L designed the study; Qi XS wrote the manuscript; Xie J and Liu NL analyzed the data and prepared the images; Yang L revised the manuscript. All the authors contributed to the study and approved the final version of the manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the Affiliated Hospital of Qingdao University, No. QYFY WZLL 30089.
Informed consent statement: The ethics committee approved the waiver of informed consent due to the retrospective nature of this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used in this study can be obtained from the corresponding author upon request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin Yang, MD, Associate Chief Physician, Department of Gastroen
Received: October 28, 2025
Revised: November 28, 2025
Accepted: December 29, 2025
Published online: February 15, 2026
Processing time: 97 Days and 17.7 Hours
Revised: November 28, 2025
Accepted: December 29, 2025
Published online: February 15, 2026
Processing time: 97 Days and 17.7 Hours
Core Tip
Core Tip: Preoperative assessment using the modified frailty index and systemic immune-inflammation index provides valuable predictive ability for evaluating surgical risk and prognosis in older patients undergoing colorectal cancer resection. Incorporating these indices into clinical practice can help healthcare providers stratify older patients with colorectal cancer based on surgical risk, allowing targeted perioperative management to improve recovery and survival rates.