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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2026; 18(1): 113681
Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.113681
Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.113681
Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma with obstructive jaundice: A case report and review of literature
Li Zhang, Pan Xiao, Lian-Dong Shi, Ke-Xin Chen, You-Fu Bing, Department of Minimally Invasive Interventional Radiology, Guilin People’s Hospital, Guilin 541000, Guangxi Zhuang Auto
Author contributions: Zhang L and Chen KX contributed to manuscript writing and editing, and data collection; Shi LD and Bin YF contributed to data analysis; Xiao P contributed to conceptualization and supervision; all authors have read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pan Xiao, MD, Research Fellow, Department of Minimally Invasive Interventional Radiology, Guilin People’s Hospital, No. 12 Wenming Road, Xiangshan District, Guilin 541000, Guangxi Zhuang Autonomous Region, China. xp13807836988@163.com
Received: September 7, 2025
Revised: October 22, 2025
Accepted: November 17, 2025
Published online: January 15, 2026
Processing time: 128 Days and 9.4 Hours
Revised: October 22, 2025
Accepted: November 17, 2025
Published online: January 15, 2026
Processing time: 128 Days and 9.4 Hours
Core Tip
Core Tip: Hepatocellular carcinoma with portal vein tumor thrombosis (PVTT) and obstructive jaundice is rare and generally carries a poor prognosis. In this case, hepatic artery infusion chemotherapy (HAIC) followed by targeted immunotherapy achieved significant tumor shrinkage, improved bilirubin levels, and regression of PVTT. The patient attained 20 months of progression-free survival and 29 months of overall survival, indicating that HAIC conversion therapy followed by targeted immunotherapy may provide an effective option when biliary drainage is not feasible.