Copyright
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2026; 18(1): 112742
Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.112742
Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.112742
Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients
Zhan-Wen Li, Zhe Liu, Sheng-Qun Liu, Department of Anesthesia and Perioperative Medicine, Henan Provincial People’s Hospital (Zhengzhou University People’s Hospital), Zhengzhou 450003, Henan Province, China
Author contributions: Li ZW was responsible for study conception, data collection, bioelectrical impedance analysis, statistical modeling, and manuscript drafting; Liu Z was responsible for methodology development, anesthesia management, clinical data collection, and manuscript revision; Liu SQ was responsible for study supervision, overall design, data interpretation, and corresponding author responsibilities; and all authors contributed to manuscript revision and approved the final version.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Henan Provincial People’s Hospital, approval No. (2021) Ethics Review 160.
Informed consent statement: Informed consent was waived due to the retrospective design and use of de-identified data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: De-identified data underlying the findings of this study are available from the corresponding author on reasonable request and subject to institutional approval.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sheng-Qun Liu, MSc, Chief Physician, Department of Anesthesia and Perioperative Medicine, Henan Provincial People’s Hospital (Zhengzhou University People’s Hospital), No. 7 Weiwu Road, Zhengzhou 450003, Henan Province, China.
Received: August 15, 2025
Revised: September 22, 2025
Accepted: December 2, 2025
Published online: January 15, 2026
Processing time: 150 Days and 2.4 Hours
Revised: September 22, 2025
Accepted: December 2, 2025
Published online: January 15, 2026
Processing time: 150 Days and 2.4 Hours
Core Tip
Core Tip: This study established a population pharmacokinetic model of rocuronium in obese patients with colorectal cancer, incorporating skeletal muscle index to explore its effect on drug distribution volume. Using nonlinear mixed-effects modeling and Monte Carlo simulation, we developed an individualized dosing strategy based on muscle mass. The findings reveal that skeletal muscle index is a significant covariate influencing rocuronium pharmacokinetic, providing a scientific basis for optimizing anesthetic dosing in obese surgical patients and enhancing patient safety during colorectal cancer surgery.