Liao LG, Xiong ZG, Hu JJ. Progress in the treatment of duodenal cancer: A comprehensive review. World J Gastrointest Oncol 2025; 17(7): 105712 [PMID: 40697222 DOI: 10.4251/wjgo.v17.i7.105712]
Corresponding Author of This Article
Jun-Jie Hu, MD, Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 116 Zuodaoquan South Road, Wuhan 430079, Hubei Province, China. 791462122@qq.com
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Oncology
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Minireviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jul 15, 2025 (publication date) through Nov 2, 2025
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Publication Name
World Journal of Gastrointestinal Oncology
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1948-5204
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Liao LG, Xiong ZG, Hu JJ. Progress in the treatment of duodenal cancer: A comprehensive review. World J Gastrointest Oncol 2025; 17(7): 105712 [PMID: 40697222 DOI: 10.4251/wjgo.v17.i7.105712]
World J Gastrointest Oncol. Jul 15, 2025; 17(7): 105712 Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.105712
Progress in the treatment of duodenal cancer: A comprehensive review
Liang-Gong Liao, Zhi-Guo Xiong, Jun-Jie Hu
Liang-Gong Liao, Zhi-Guo Xiong, Jun-Jie Hu, Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, Hubei Province, China
Liang-Gong Liao, Zhi-Guo Xiong, Jun-Jie Hu, Hubei Provincial Clinical Research Center for Colorectal Cancer, Wuhan 430079, Hubei Province, China
Liang-Gong Liao, Zhi-Guo Xiong, Jun-Jie Hu, Wuhan Clinical Research Center for Colorectal Cancer, Wuhan 430079, Hubei Province, China
Author contributions: Hu JJ conceived the study; Liao LG and Xiong ZG wrote the manuscript; All authors read and approved the final manuscript.
Supported by Research Projects of Biomedical Center of Hubei Cancer Hospital, No. 2022SWZX07; 2023-2024 Annual Scientific Research Project of Traditional Chinese Medicine from Hubei Provincial Administration of Traditional Chinese Medicine, No. ZY2023Z005; and Health Commission of Hubei Province Scientific Research Project, No. WJ2023Z011.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun-Jie Hu, MD, Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 116 Zuodaoquan South Road, Wuhan 430079, Hubei Province, China. 791462122@qq.com
Received: February 5, 2025 Revised: April 4, 2025 Accepted: May 30, 2025 Published online: July 15, 2025 Processing time: 160 Days and 9.6 Hours
Core Tip
Core Tip: Duodenal cancer, a rare gastrointestinal malignancy, requires multidisciplinary strategies. Endoscopic resection for early-stage tumors improves survival and reduces infection mortality. Advanced cases benefit from surgery and minimally invasive techniques. Chemotherapy and neoadjuvant chemoradiotherapy enhance outcomes. Targeted therapies such as erb-b2 receptor tyrosine kinase 2 (human epidermal growth factor receptor 2)/phosphatidylinositol-3-kinase inhibitors and immunotherapy show transformative potential. Molecular profiling guides precision medicine. International collaboration is critical to optimize biomarker-driven strategies and improve survival. This review integrates innovations in surgery, systemic therapy, and immunotherapy, offering a roadmap for personalized management.
