Esophageal squamous cell carcinoma susceptibility of activin A receptor type 1C variants in Chinese population

doi:10.4251/wjgo.v17.i6.102687

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Jun 15, 2025 (publication date) through Feb 17, 2026

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastrointest Oncol. Jun 15, 2025; 17(6): 102687
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.102687

Esophageal squamous cell carcinoma susceptibility of activin A receptor type 1C variants in Chinese population

Shashank Kumar

Shashank Kumar, Department of Biochemistry, Central University of Punjab, Bathinda 151401, Punjab, India

Author contributions: Kumar S wrote the original draft, conceptualization, writing, reviewing and editing; read and approved the final version of the manuscript to be published.

Conflict-of-interest statement: Author declares no conflicts of interest.

Corresponding author: Shashank Kumar, PhD, Assistant Professor, Department of Biochemistry, Central University of Punjab, VPO Ghudda, Bathinda 151401, Punjab, India. shashankbiochemau@gmail.com

Received: October 28, 2024
Revised: January 28, 2025
Accepted: February 11, 2025
Published online: June 15, 2025
Processing time: 231 Days and 2.8 Hours

Core Tip

Core Tip: The present hospital-based case-control study investigates the activin A receptor type 1C (ACVR1C) single nucleotide polymorphisms association with the esophageal squamous cell carcinoma (ESCC) risk in a very small population. The author tried to stratify the association with the demographic profile of the patients but lacked association with the clinical characteristics of the test patients. ACVR1C expression should be studied in the samples as it is associated with cancer hallmarks and clinical outcomes in a cancer context-dependent manner. Next, the author should include the patients getting ESCC therapy as one of the groups as ACVR1C expression plays a role in chemotherapeutic response to cancer. These measures will provide useful information for clinical practice.