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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2025; 17(12): 114173
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.114173
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.114173
miR-136: A biomarker in the inflammation-cancer transformation of gastric cancer
Hao Lyu, Jia-Si Chen, Jing-Feng Tang, Ce-Fan Zhou, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, Hubei Province, China
Co-first authors: Hao Lyu and Jia-Si Chen.
Author contributions: Lyu H and Chen JS contributed equally to this study as co-first authors; Lyu H prepared and wrote the original draft; Chen JS collaboratively drafted the manuscript; Zhou CF contributed to the conceptualization, writing, review, and editing of the manuscript; Tang JF provided some valuable opinions; all authors have reviewed and approved the final version of the manuscript.
Supported by National Natural Science Foundation of China, No. 32270768, No. 82273970, and No. 82370715.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ce-Fan Zhou, PhD, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China.
Received: September 15, 2025
Revised: October 11, 2025
Accepted: October 29, 2025
Published online: December 15, 2025
Processing time: 89 Days and 20.4 Hours
Revised: October 11, 2025
Accepted: October 29, 2025
Published online: December 15, 2025
Processing time: 89 Days and 20.4 Hours
Core Tip
Core Tip: Helicobacter pylori (H. pylori)-induced inflammation plays a crucial role in the development of gastric cancer (GC). A comprehensive understanding of the molecular mechanisms driven by H. pylori infection in the development of GC is essential for the timely diagnosis of tumors and the formulation of corresponding personalized treatment strategies. Reviewing the mechanisms of inflammation-cancer transformation induced by H. pylori infection in GC, will help in identifying potential patient stratification factors and formulating personalized treatment strategies for GC patients.