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Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2025; 17(11): 112089
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.112089
Clinicopathological characteristics and surgical value of primary gastrointestinal lymphoma
Cong-Xian Yang, Lin-Xiang Xu, Jing Liu, Hui-Lian Qiao, Zhi-Wei Dong, Dan Jiang, Guo-Li Gu
Cong-Xian Yang, Lin-Xiang Xu, Graduate School, Hebei North University, Zhangjiakou 705132, Hebei Province, China
Jing Liu, Zhi-Wei Dong, Guo-Li Gu, Department of General Surgery, Air Force Medical Center, Chinese PLA, Beijing 100142, China
Hui-Lian Qiao, Department of Pathology, Air Force Medical Center, Chinese PLA, Beijing 100142, China
Dan Jiang, Department of Anesthesiology, Air Force Medical Center, Chinese PLA, Beijing 100142, China
Co-first authors: Cong-Xian Yang and Lin-Xiang Xu.
Co-corresponding authors: Dan Jiang and Guo-Li Gu.
Author contributions: Yang CX, Xu LX, and Liu J wrote the manuscript; Yang CX, Xu LX, Liu J, and Qiao HL collected and analyzed the clinical data; Dong ZW managed the patients, collected and analyzed the clinical data; Jiang D and Gu GL designed the research, provided the material support, and revised the manuscript; All authors approved the final manuscript. Yang CX and Xu LX contributed equally to this article and are the co-first authors of this manuscript. Jiang D and Gu GL contributed equally to this article and are the co-corresponding authors of this manuscript.
Supported by the Outstanding Young Talents Program of Air Force Medical Center, People’s Liberation Army, No. 22BJQN004; and Clinical Program of Air Force Medical University, No. Xiaoke2022-07.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Affiliated Air Force Medical Center, No. 2025-95-PJ01.
Informed consent statement: The analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written informed consent.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Li Gu, MD, Chief doctor, Department of General Surgery, Air Force Medical Center, China PLA, No. 30 Fucheng Road, Haidian District, Beijing 100142, China. kzggl@163.com
Received: July 29, 2025
Revised: August 25, 2025
Accepted: October 22, 2025
Published online: November 15, 2025
Processing time: 107 Days and 17.3 Hours
Core Tip

Core Tip: Primary gastrointestinal lymphoma predominantly manifests as diffuse large B-cell lymphoma, with abdominal pain as the leading symptom. Comprehensive diagnosis relies on imaging (computed tomography sensitivity: 94.3%) and endoscopic biopsy (detection rate: 91.5%). Surgery is pivotal for definitive diagnosis (via complete specimen acquisition), emergency management (e.g., obstruction/perforation), and primary lesion resection, particularly for tumors > 5 cm (26.5% complication rate). While combined surgery and chemotherapy showed higher improvement rates than chemotherapy alone, statistical significance was not reached. Integration of surgical strategies into multimodal therapy may optimize outcomes, emphasizing individualized approaches based on tumor size, stage, and complications.