Elsayed MOK. Treatment of recurrent hepatocellular carcinoma: The current standards and future perspectives. World J Gastrointest Oncol 2025; 17(11): 110735 [DOI: 10.4251/wjgo.v17.i11.110735]
Corresponding Author of This Article
Mohammed Omar Khalifa Elsayed, MD, FRCP, Professor, Department of Gastroenterology, South Tees Hospitals NHS Foundation Trust, The James Cook University Hospital, Marton Road, Middlesbrough TS4 3BW, United Kingdom. dmohammed_omar_76@outlook.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 15, 2025 (publication date) through Nov 13, 2025
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Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Oncology
ISSN
1948-5204
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Elsayed MOK. Treatment of recurrent hepatocellular carcinoma: The current standards and future perspectives. World J Gastrointest Oncol 2025; 17(11): 110735 [DOI: 10.4251/wjgo.v17.i11.110735]
World J Gastrointest Oncol. Nov 15, 2025; 17(11): 110735 Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.110735
Treatment of recurrent hepatocellular carcinoma: The current standards and future perspectives
Mohammed Omar Khalifa Elsayed
Mohammed Omar Khalifa Elsayed, Department of Gastroenterology, South Tees Hospitals NHS Foundation Trust, The James Cook University Hospital, Middlesbrough TS4 3BW, United Kingdom
Author contributions: Elsayed MOK wrote and revised the review and submitted it for publication.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammed Omar Khalifa Elsayed, MD, FRCP, Professor, Department of Gastroenterology, South Tees Hospitals NHS Foundation Trust, The James Cook University Hospital, Marton Road, Middlesbrough TS4 3BW, United Kingdom. dmohammed_omar_76@outlook.com
Received: June 13, 2025 Revised: June 29, 2025 Accepted: October 9, 2025 Published online: November 15, 2025 Processing time: 154 Days and 2.8 Hours
Core Tip
Core Tip: Recurrent hepatocellular carcinoma (HCC) is indeed an increasing concern, especially as the global incidence of chronic liver diseases continues to rise. The management of recurrent HCC remains complex, particularly after liver transplantation or hepatic resection, as there is no universally agreed-upon approach. Several treatment modalities are available as locoregional and systemic therapies, and each comes with its own set of advantages and challenges. As recurrent HCC becomes more prevalent, developing a clear, evidence-based treatment approach will be crucial. Further research and prospective randomized trials are essential to determine the best management strategies, establish guidelines, and improve long-term patient outcomes in this challenging clinical scenario.
