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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2025; 17(11): 109375
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.109375
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.109375
Short-term and long-term effects of sevoflurane inhalation vs propofol total intravenous anesthesia in gastrectomy for gastric cancer
Zhi Wang, Department of Anesthesiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, Shandong Province, China
Ji-Wen Cheng, Department of Oncology, Qingdao Municipal Hospital, Qingdao 266000, Shandong Province, China
Kuai-Yun Yu, Department of General Surgery, Yantaishan Hospital, Yantai 264001, Shandong Province, China
Author contributions: Wang Z designed the experiments and conducted clinical data collection; Cheng JW performed postoperative follow-up and recorded the data, conducted the collation and statistical analysis; Wang Z and Yu KY make critical revisions to important knowledge content; all authors read and approved the final manuscript.
Institutional review board statement: This study has been approved by the Ethics Committee of Yantaishan Hospital, No. 2024163.
Informed consent statement: The ethics committee of the institution agreed to waive informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kuai-Yun Yu, Department of General Surgery, Yantaishan Hospital, No. 91 Jiefang Road, Zhifu District, Yantai 264001, Shandong Province, China.
Received: July 29, 2025
Revised: September 5, 2025
Accepted: October 13, 2025
Published online: November 15, 2025
Processing time: 107 Days and 17 Hours
Revised: September 5, 2025
Accepted: October 13, 2025
Published online: November 15, 2025
Processing time: 107 Days and 17 Hours
Core Tip
Core Tip: This study compares sevoflurane inhalation anesthesia with propofol total intravenous anesthesia in patients undergoing radical gastrectomy for gastric cancer. Both anesthetic techniques showed equivalent intraoperative safety and postoperative outcomes, including complications, pain scores, and long-term survival. Importantly, the propofol group exhibited higher postoperative nausea incidence and transiently elevated blood pressure and heart rate during surgery. These findings suggest that the choice of anesthetic can be individualized based on patient-specific factors without compromising perioperative or oncologic outcomes.