Innovative insights into gut microbiota modulation in colorectal cancer: From microbial dysbiosis to therapeutic strategies

doi:10.4251/wjgo.v17.i11.108747

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Nov 15, 2025 (publication date) through Nov 13, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastrointest Oncol. Nov 15, 2025; 17(11): 108747
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.108747

Innovative insights into gut microbiota modulation in colorectal cancer: From microbial dysbiosis to therapeutic strategies

Semra Demirli Atici

Semra Demirli Atici, Department of General Surgery, Acibadem Kent Hospital, Izmir 35620, Türkiye

Author contributions: Demirli Atici S prepared, collected literature, performed analysis and wrote the manuscript, read and agreed to the published version of the manuscript.

Conflict-of-interest statement: The author declares no conflict of interest in publishing the manuscript.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Semra Demirli Atici, MD, Department of General Surgery, Acibadem Kent Hospital, Ataşehir Mahallesi 8229/1, Sokak, Izmir 35620, Türkiye. smrdemirli@hotmail.com

Received: April 22, 2025
Revised: June 2, 2025
Accepted: June 27, 2025
Published online: November 15, 2025
Processing time: 206 Days and 6.3 Hours

Core Tip

Core Tip: This article clarifies the complex involvement of the gut microbiota in colorectal cancer (CRC), emphasizing the influence of microbial metabolites, immunological interactions, biofilm formation, and the therapeutic potential of fecal microbiota transplantation. It also presents innovative future directions, including engineered probiotics and microbiota-informed risk stratification models, which may advance precision oncology in CRC care.