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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2025; 17(10): 111509
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.111509
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.111509
Gut microbiota and metabolite changes in metastatic colorectal cancer via 16S rRNA and metabolomics
Pan Deng, Hua Lin, Department of General Surgery, Xiangya Changde Hospital, Changde 415009, Hunan Province, China
Hu Zeng, Department of Hepatobiliary Surgery, The Sixth Affiliated Hospital of Jinan Uni
Feng Guo, Department of Interventional Diagnosis and Treatment, The Central Hospital of Yongzhou, Yongzhou 425002, Hunan Province, China
Co-first authors: Pan Deng and Hua Lin.
Co-corresponding authors: Hu Zeng and Feng Guo.
Author contributions: Zeng H and Guo F designed the study; While Deng P and Lin H executed the research.
Institutional review board statement: The study protocol was approved by the Institutional Ethics Committee of Xiangya Changde Hospital (No. 2021-06).
Informed consent statement: All participants in this study voluntarily provided their written informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: To protect patient privacy, research data will not be made public. If necessary, please contact the corresponding author to obtain it.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Guo, MD, Doctor, Department of Interventional Diagnosis and Treatment, The Central Hospital of Yongzhou, No. 396 Yiyun Road, Lengshuitan District, Yongzhou 425002, Hunan Province, China. search_gf@163.com
Received: July 8, 2025
Revised: August 20, 2025
Accepted: September 24, 2025
Published online: October 15, 2025
Processing time: 97 Days and 23.8 Hours
Revised: August 20, 2025
Accepted: September 24, 2025
Published online: October 15, 2025
Processing time: 97 Days and 23.8 Hours
Core Tip
Core Tip: Colorectal cancer patients with different metastatic statuses exhibit distinct gut microbiota and metabolite profiles. These differences may contribute to cancer progression and metastasis, providing potential biomarkers for early diagnosis and therapeutic targets.