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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2025; 17(10): 109744
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.109744
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.109744
Helicobacter pylori-induced miR-136 is a potential predictor of early-stage gastric cancer
Tao Chen, The First Clinical Medical College of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Tao Chen, An-Qiang Feng, Department of Gastroenterology, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province, China
Xiao-Ran Shen, Department of Gastroenterology, Nantong First People’s Hospital, Nantong 226001, Jiangsu Province, China
Ni-Yi Dang, Feng Ye, Guo-Xin Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Co-first authors: Tao Chen and An-Qiang Feng.
Author contributions: Chen T, Feng AQ, Shen XR, Ye F, Dang NY, and Zhang GX contributed to this work; Chen T and Zhang GX contributed to the study design; Chen T, Feng AQ, and Shen XR contributed to the collection, analysis, and interpretation of data; Chen T contributed to drafting the manuscript; Zhang GX contributed to study supervision; All authors contributed to revision of the manuscript and read and approved the manuscript.
Supported by the National Natural Science Foundation of China, No. 82470593; and General Project of the Development Fund of the Affiliated Hospital of Xuzhou Medical University, No. XYFM202334.
Institutional review board statement: This study was approved by the Ethics Committee of the Xuzhou Central Hospital (Approval No. XZXY-LJ-20180627-004). All the recruited subjects signed the consent forms.
Institutional animal care and use committee statement: All animal studies (including the mice euthanasia procedure) were done in compliance with the regulations and guidelines of Xuzhou Central Hospital institutional animal care and conducted according to the AAALAC and the IACUC guidelines (Ministry of Science and Technology of China, 2006). The animal study was reviewed and approved by Xuzhou Central Hospital Animal Ethic Committee (Approval No. XZYKDX-20200721-005).
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Xin Zhang, PhD, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. nanjingmedical@163.com
Received: May 21, 2025
Revised: July 7, 2025
Accepted: August 25, 2025
Published online: October 15, 2025
Processing time: 147 Days and 4.8 Hours
Revised: July 7, 2025
Accepted: August 25, 2025
Published online: October 15, 2025
Processing time: 147 Days and 4.8 Hours
Core Tip
Core Tip: Helicobacter pylori infection upregulates miR-136, promoting gastric cancer progression by suppressing PDCD11 via nuclear factor kappa-B activation. This study identified miR-136 as a potential diagnostic biomarker and therapeutic target for early-stage gastric cancer, demonstrating its role in tumor growth and metastasis through in vitro and in vivo models. Targeting the nuclear factor kappa-B/miR-136/PDCD11 axis may offer new strategies for intervention.