Dong Y, Chen LP, He JG, Yang QQ, Hu ZW. Clinical value of contrast-enhanced ultrasound in early diagnosis of hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(10): 109506 [PMID: 41114101 DOI: 10.4251/wjgo.v17.i10.109506]
Corresponding Author of This Article
Zhi-Wen Hu, MM, Attending Doctor, Department of Medical Ultrasound, Guangzhou First People’s Hospital (Second Affiliated Hospital of South China University of Technology), No. 1 Panfu Road, Guangzhou 510180, Guangdong Province, China. charleyhu@163.com
Research Domain of This Article
Gastroenterology & Hepatology
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Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 15, 2025 (publication date) through Feb 23, 2026
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Publication Name
World Journal of Gastrointestinal Oncology
ISSN
1948-5204
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Dong Y, Chen LP, He JG, Yang QQ, Hu ZW. Clinical value of contrast-enhanced ultrasound in early diagnosis of hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(10): 109506 [PMID: 41114101 DOI: 10.4251/wjgo.v17.i10.109506]
World J Gastrointest Oncol. Oct 15, 2025; 17(10): 109506 Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.109506
Clinical value of contrast-enhanced ultrasound in early diagnosis of hepatocellular carcinoma
Yan Dong, Li-Ping Chen, Jing-Guang He, Qing-Qing Yang, Zhi-Wen Hu
Yan Dong, Li-Ping Chen, Jing-Guang He, Zhi-Wen Hu, Department of Medical Ultrasound, Guangzhou First People’s Hospital (Second Affiliated Hospital of South China University of Technology), Guangzhou 510180, Guangdong Province, China
Qing-Qing Yang, Department of Medical Ultrasound, The Second People’s Hospital of Baiyun, Guangzhou 510450, Guangdong Province, China
Co-first authors: Yan Dong and Li-Ping Chen.
Author contributions: Dong Y and Chen LP contributed equally to this manuscript and are co-first authors. Dong Y and Hu ZW proposed the concept of this study and participated in data collection; Dong Y drafted the initial draft; Chen LP, He JG, and Yang QQ contributed to the formal analysis of this study; Chen LP and Hu ZW guided the research, methodology, and visualization of the manuscript; Dong Y, Chen LP, He JG, Yang QQ, and Hu ZW participated in this study, validated it, and jointly reviewed and edited the manuscript.
Supported by Science and Technology Program of Chinese Medicine and Integrated Chinese and Western Medicine in Guangzhou, No. 20252A010001; and Science and Technology Program of Guangzhou, No. 2024A03J1029.
Institutional review board statement: This research has been reviewed and approved by the Ethics Committee of Guangzhou First People’s Hospital, approval No. B-2024-003-03.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No available data.
Corresponding author: Zhi-Wen Hu, MM, Attending Doctor, Department of Medical Ultrasound, Guangzhou First People’s Hospital (Second Affiliated Hospital of South China University of Technology), No. 1 Panfu Road, Guangzhou 510180, Guangdong Province, China. charleyhu@163.com
Received: June 10, 2025 Revised: July 10, 2025 Accepted: August 21, 2025 Published online: October 15, 2025 Processing time: 125 Days and 23.7 Hours
Core Tip
Core Tip: Contrast-enhanced ultrasound (CEUS) plays an important role in the early diagnosis of hepatocellular carcinoma. By observing characteristic enhancement patterns - such as arterial phase hyperenhancement and portal/delayed phase washout - CEUS provides critical insights into tumor vascularity and behavior. Quantitative indicators such as arterial phase time and peak enhancement intensity further improve diagnostic accuracy. Compared with computed tomography or magnetic resonance imaging, CEUS offers advantages including real-time imaging, lower cost, no ionizing radiation, and better sensitivity for small or early-stage lesions. These strengths support its use in early detection, pathological correlation, and timely clinical intervention for hepatocellular carcinoma.
