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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2025; 17(10): 108410
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.108410
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.108410
Molecular mechanism of modified Yigong San formula against colorectal cancer via EZH2/METTL3/SOX4 pathway-mediated apoptosis
Jing Wang, The First Clinical School, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China
Xin-Wei Zhang, Department of Integrated Traditional Chinese and Western Medicine Medical Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning Province, China
Bo-Wen Tang, College of Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China
Zheng Li, Key Laboratory of Ministry of Education for Traditional Chinese Medicine Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China
Nan Song, Medical Laboratory Science School, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China
Co-first authors: Jing Wang and Xin-Wei Zhang.
Co-corresponding authors: Zheng Li and Nan Song.
Author contributions: Song N and Li Z conceived the work, supervised the writing, and provided intellectual input, they contributed equally to this manuscript and are co-corresponding authors; Wang J responsible for thesis writing and part of experiments; Zhang XW responsible for translation of papers and part of experiments; Tang BW responsible for thesis experiments. Wang J and Zhang XW contributed equally to this study and are co-first authors.
Supported by Liaoning Provincial Science and Technology Department Project, No. 2023JH2/101700149; and Open Fund Project of Liaoning University of Traditional Chinese Medicine, No. zyzx2205.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Liaoning Cancer Hospital & Institute, No. KY20240341.
Institutional animal care and use committee statement: All animal husbandry and experiments were conducted in strict accordance with the regulations for the care and use of laboratory animals, approved by the Institutional Animal Care and Use Committee of the Liaoning University of Traditional Chinese Medicine, No. 2021012125.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All authors agree data sharing.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zheng Li, Key Laboratory of Ministry of Education for Traditional Chinese Medicine Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Huanggu District, Shenyang 110847, Liaoning Province, China. fox_dl1984@163.com
Received: May 14, 2025
Revised: June 19, 2025
Accepted: August 7, 2025
Published online: October 15, 2025
Processing time: 152 Days and 23.2 Hours
Revised: June 19, 2025
Accepted: August 7, 2025
Published online: October 15, 2025
Processing time: 152 Days and 23.2 Hours
Core Tip
Core Tip: In this study, SW-480 cells were used as experimental subjects. Quantitative reverse transcription polymerase chain reaction, western blot, cell scratch assay, flow cytometry and other experimental methods were used to explore the expression of genes such as methyltransferase-like 3 (METTL3), enhancer of zeste homolog 2 (EZH2), SRY-box tran