Kong S, Xu YH, Zheng M, Ju SQ, Shi HC. Circ_0004592: An auxiliary diagnostic biomarker for gastric cancer. World J Gastrointest Oncol 2024; 16(6): 2757-2768 [PMID: 38994162 DOI: 10.4251/wjgo.v16.i6.2757]
Corresponding Author of This Article
Shao-Qing Ju, DPhil, Professor, Department of Laboratory Medicine, The Affiliated Hospital of Nantong University, No. 20 Xisi Road, Nantong 226001, Jiangsu Province, China. mucunmeishan1130@qq.com
Research Domain of This Article
Medical Laboratory Technology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jun 15, 2024 (publication date) through Oct 30, 2025
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Oncology
ISSN
1948-5204
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Kong S, Xu YH, Zheng M, Ju SQ, Shi HC. Circ_0004592: An auxiliary diagnostic biomarker for gastric cancer. World J Gastrointest Oncol 2024; 16(6): 2757-2768 [PMID: 38994162 DOI: 10.4251/wjgo.v16.i6.2757]
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2757-2768 Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2757
Circ_0004592: An auxiliary diagnostic biomarker for gastric cancer
Shan Kong, Yan-Hua Xu, Ming Zheng, Shao-Qing Ju, Heng-Chuan Shi
Shan Kong, Heng-Chuan Shi, Department of Laboratory Medicine, Jiangsu Province Official Hospital, Nanjing 210000, Jiangsu Province, China
Yan-Hua Xu, Department of Laboratory Medicine, Northern Jiangsu People’s Hospital, Yangzhou 225000, Jiangsu Province, China
Ming Zheng, Shao-Qing Ju, Department of Laboratory Medicine, The Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Co-first authors: Shan Kong and Yan-Hua Xu.
Co-corresponding authors: Shao-Qing Ju and Heng-Chuan Shi.
Author contributions: Kong S and Xu YH collected the related data for the manuscript and drafted it; Zheng M collected samples; Ju SQ participated in the design of the research; Shi HC helped to draft and modify the manuscript; and all authors read and approved the final manuscript.
Supported bythe Jiangsu Province Laboratory Medical Research Special Fund Project, No. SYH-3201160-0061(2023008).
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Affiliated Hospital of Nantong University (Approval No. 2020-L038).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data and materials are available from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shao-Qing Ju, DPhil, Professor, Department of Laboratory Medicine, The Affiliated Hospital of Nantong University, No. 20 Xisi Road, Nantong 226001, Jiangsu Province, China. mucunmeishan1130@qq.com
Received: January 29, 2024 Revised: March 12, 2024 Accepted: April 12, 2024 Published online: June 15, 2024 Processing time: 137 Days and 9.8 Hours
Core Tip
Core Tip: Circ_0004592 was significantly overexpressed in gastric cancer (GC) tissues and plasma. Reverse transcription and real-time fluorescent quantitative polymerase chain reaction was validated as a robust approach for the detection of circ_0004592. The expression level of circ_0004592 in the plasma of patients with precancerous lesions was increased relative to that in healthy controls, suggesting that plasma circ_0004592 may serve as an early diagnostic biomarker. Further, its levels in plasma decreased following surgical resection of gastric tumors. High circ_0004592 expression was associated with the histological type, depth of tumor invasion, and lymph node metastasis of GC. These observations highlight the potential of circ_0004592 as a valuable diagnostic and prognostic biomarker.
