Advancements in breath-based diagnostics for pancreatic cancer: Current insights and future perspectives

doi:10.4251/wjgo.v16.i6.2300

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Jun 15, 2024 (publication date) through Feb 13, 2026

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2300-2303
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2300

Advancements in breath-based diagnostics for pancreatic cancer: Current insights and future perspectives

Mesut Tez, Eda Şahingöz, Hüseyin Fahri Martlı

Mesut Tez, Department of Surgery, University of Health Sciences, Ankara City Hospital, Ankara 06800, Türkiye

Eda Şahingöz, Department of General Surgery, Sağlık Bilimleri University, Ankara 06100, Türkiye

Hüseyin Fahri Martlı, Department of General Surgery, Ankara City Hospital, Ankara 06100, Türkiye

Author contributions: Tez M, Şahingöz E, and Martlı HF wrote the manuscript; and all of the authors have read and approved the final manuscript.

Conflict-of-interest statement: There is no conflict of interest to declare.

Corresponding author: Mesut Tez, MD, Chief Physician, Department of Surgery, University of Health Sciences, Ankara City Hospital, District of Universities, No. 1 Bilkent Street, Ankara 06800, Türkiye. mesuttez@yahoo.com

Received: January 14, 2024
Revised: April 19, 2024
Accepted: April 29, 2024
Published online: June 15, 2024
Processing time: 152 Days and 12.8 Hours

Core Tip

Core Tip: This study delves into the potential of volatile organic compounds (VOCs) in exhaled breath as non-invasive biomarkers for distinguishing pancreatic ductal adenocarcinoma (PDAC) from intraductal papillary mucinous neoplasm and healthy individuals. Through breath analysis, distinct VOC profiles, particularly dimethyl sulfide and acetone dimer, emerge as promising candidates for PDAC identification. Acetone dimer surpasses the established biomarker carbohydrate antigen 19-9 in diagnostic performance, showcasing its relevance in early detection. Despite study limitations, these findings open avenues for further research, emphasizing the need for standardized methodologies and larger-scale investigations in the realm of breath-based diagnostics for pancreatic cancer.