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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2024; 16(12): 4716-4727
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4716
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4716
Enhancing the radiosensitivity of colorectal cancer cells by reducing spermine synthase through promoting autophagy and DNA damage
Yu-Bin Guo, Yue-Ming Wu, Zhi-Zhao Lin, Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: Guo YB, Wu YM and Lin ZZ contributed to study concept and design; Wu YM and Lin ZZ contributed to analysis and interpretation of data; Guo YB contributed to drafting of the manuscript; Lin ZZ contributed to critical revision of the manuscript for important intellectual content; Wu YM contributed to statistical analysis; All authors contributed to study supervision and have read and approved the manuscript.
Supported by National Natural Science Foundation of China, No. 82102996; Guangdong Provincial Natural Science Foundation, No. 2022A1515010517; Guangzhou Science and Technology Plan Project, No. 202201011016; and President Foundation of Nanfang Hospital, Southern Medical University, No. 2020C038.
Institutional animal care and use committee statement: This study did not involve animal or clinical trials and did not require ethics. Normal colonic epithelial cells FHC (CRL-1831), CRC cell line HCT116 (CRL-247), SW62, SW480, HT-29, and LoVo cells were all purchased from WHELAB.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: The data used to support the findings of this study are available from the corresponding author upon request at 928526639@qq.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Bin Guo, PhD, Attending Doctor, Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou 510515, Guangdong Province, China. 928526639@qq.com
Received: June 17, 2024
Revised: September 3, 2024
Accepted: October 18, 2024
Published online: December 15, 2024
Processing time: 148 Days and 4.4 Hours
Revised: September 3, 2024
Accepted: October 18, 2024
Published online: December 15, 2024
Processing time: 148 Days and 4.4 Hours
Core Tip
Core Tip: This study highlighted spermine synthase (SMS) as a pivotal molecule regulating DNA damage and autophagy in cancer cells. SMS promoted DNA repair and activated the mammalian target of rapamycin signaling pathway, resulting in the inhibition of cellular autophagy. Collectively, SMS emerges as a promising therapeutic target to enhance colorectal cancer radiosensitivity, providing novel insights into the development of colorectal cancer treatment strategies.