Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2024; 16(12): 4685-4699
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4685
Vitamin D 1,25-Dihydroxyvitamin D3 reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization
Wen-Jing Luo, Xian-Wen Dong, Hua Ye, Qiao-Su Zhao, Qiu-Bo Zhang, Wen-Ying Guo, Hui-Wei Liu, Feng Xu
Wen-Jing Luo, Xian-Wen Dong, Hua Ye, Qiao-Su Zhao, Qiu-Bo Zhang, Wen-Ying Guo, Hui-Wei Liu, Feng Xu, Department of Gastroenterology, Ningbo Medical Center Lihuili Hospital, Ningbo 315000, Zhejiang Province, China
Author contributions: Luo WJ, Dong XW and Ye H designed the research study; Zhao QS, Zhang QB and Guo WY performed the research; Liu HW and Xu F conducted experiments, analyzed the data; All authors contributed to editorial changes in the manuscript; All authors read and approved the final manuscript.
Supported by the Natural Science Foundation of Ningbo, No. 202003N4234; and Medical and Health Research Project of Zhejiang Province, No. 2024KY1477.
Institutional animal care and use committee statement: This study was approved by the Ningbo University Animal Care and Use Committee according to the criteria set by Ningbo Medical Center Lihuili Hospital, No. IACUC202013.
Conflict-of-interest statement: The authors declare that they have no competing interests
Data sharing statement: The datasets used and analysed during the current study are available from the corresponding author on reasonable request at xufeng200468@126.com.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Xu, MAMS, Chief Physician, Department of Gastroenterology, Ningbo Medical Center Lihuili Hospital, No. 57 Xingning Road, Ningbo 315000, Zhejiang Province, China. xufeng200468@126.com
Received: April 16, 2024
Revised: September 9, 2024
Accepted: October 8, 2024
Published online: December 15, 2024
Processing time: 210 Days and 3 Hours
Core Tip

Core Tip: Supplementation with 1,25-dihydroxy-vitamin D [1,25(OH)2D3] improved hepatic steatosis and lipid metabolism in nonalcoholic fatty liver disease, linked to its capacity to reverse the proinflammatory M1 polarization of hepatic macrophages, partially by regulating the vitamin D receptor-peroxisome proliferator activated receptor γ pathway. The involvement of 1,25(OH)2D3 in inhibiting fatty-acid-induced proinflammatory M1 polarization of macrophages played a direct role in relieving lipid accumulation and metabolism in hepatocytes.