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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2024; 16(12): 4625-4635
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4625
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4625
Risk factors for hepatocellular carcinoma in cirrhosis: A comprehensive analysis from a decade-long study
Da-Qiong Zhou, Jiang-Yu Liu, Jing Zhang, Li-Li Liu, Zhen-Huan Cao, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Feng Zhao, Jian-Ru Jia, Hepatology Center, Baoding People’s Hospital, Baoding 071000, Hebei Province, China
Co-first authors: Da-Qiong Zhou and Jiang-Yu Liu.
Co-corresponding authors: Jian-Ru Jia and Zhen-Huan Cao.
Author contributions: Zhou DQ, Liu JY, and Zhao F analyzed the data and wrote the manuscript; Zhang J and Liu LL collected the data and contributed analytic tools; Jia JR and Cao ZH designed the research study and revised the manuscript.
Institutional review board statement: The protocol and consent form for the study were approved by the research ethics committee of Beijing Youan Hospital, Capital Medical University, Notification of Ethical Review Opinions (No. 2024051).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Data sharing statement: The data used to support the findings are available from the corresponding author upon request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Huan Cao, Doctor, Professor, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, No. 8 Xitoutiao, You’anmen Wai, Fengtai District, Beijing 100069, China. caozhenhuanyu@mail.ccmu.edu.cn
Received: May 9, 2024
Revised: August 28, 2024
Accepted: October 9, 2024
Published online: December 15, 2024
Processing time: 187 Days and 8.6 Hours
Revised: August 28, 2024
Accepted: October 9, 2024
Published online: December 15, 2024
Processing time: 187 Days and 8.6 Hours
Core Tip
Core Tip: Our retrospective analysis spanned a decade (January 1, 2012 to September 30, 2022) and included 5417 patients from Beijing Youan Hospital, Capital Medical University. Using Cox regression and competing risk regression models, we identified several key factors that significantly contributed to the risk of hepatocellular carcinoma in patients with cirrhosis. Specifically, this study underscores the increased association of hepatitis B cirrhosis with hepatocellular carcinoma incidence and highlights other significant risk factors, including male sex, advanced age, viral hepatitis-related cirrhosis, elevated blood ammonia, and lower albumin and platelet levels.