Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2023; 15(6): 1086-1095
Published online Jun 15, 2023. doi: 10.4251/wjgo.v15.i6.1086
Diagnostic value of circular free DNA for colorectal cancer detection
Yao Cui, Lu-Jin Zhang, Jian Li, Yu-Jie Xu, Ming-Yue Liu
Yao Cui, Lu-Jin Zhang, Yu-Jie Xu, Ming-Yue Liu, Department of Oncology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan University People's Hospital, Zhengzhou 450003, Henan Province, China
Jian Li, Department of General Surgery, Henan Tumor Hospital, The Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Author contributions: Cui Y and Liu MY designed the study; Zhang LJ, Li J and Xu YJ performed the research; Cui Y and Li J analyzed the data; Cui Y wrote the manuscript; Cui Y and Liu MY revised the manuscript for final submission; Liu MY is the corresponding author.
Supported by the Henan Medical Science and Technology Research Program, No. LHGJ20210045.
Institutional review board statement: The study was reviewed and approved by the Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan University People's Hospital.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We declare that we have no financial or personal relationships with other individuals or organizations that can inappropriately influence our work and that there is no professional or other personal interest of any nature in any product, service and/or company that could be construed as influencing the position presented in or the review of the manuscript.
Data sharing statement: We have no data to share.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Yue Liu, MD, Doctor, Department of Oncology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan University People's Hospital, No. 7 Weiwu Road, Zhengzhou 450003, Henan Province, China. liumingyuezz@163.com
Received: March 13, 2023
Peer-review started: March 13, 2023
First decision: March 28, 2023
Revised: March 29, 2023
Accepted: May 17, 2023
Article in press: May 17, 2023
Published online: June 15, 2023
Processing time: 94 Days and 3.1 Hours
Core Tip

Core Tip: Minimally invasive or noninvasive, sensitive and accurate detection of colorectal cancer (CRC) is urgently needed in clinical practice. We aimed to build a joint diagnostic model based on circular free DNA for detection of colorectal cancer. We evaluated the diagnostic value of circular free CAMK1D DNA for differentiating between HC individuals and CRC patients and demonstrated that CAMK1D may represent a potential diagnostic biomarker for CRC detection. Further analysis should use the colorectal polyp group to validate the diagnostic model in future studies.