Jiang KL, Wang XX, Liu XJ, Guo LK, Chen YQ, Jia QL, Yang KM, Ling JH. Success rate of current human-derived gastric cancer organoids establishment and influencing factors: A systematic review and meta-analysis. World J Gastrointest Oncol 2024; 16(4): 1626-1646 [PMID: 38660634 DOI: 10.4251/wjgo.v16.i4.1626]
Corresponding Author of This Article
Jiang-Hong Ling, PhD, Professor, Department of Gastroenterology, Shuguang Hospital, No. 185 Pu’an Road, Huangpu District, Shanghai 200021, China. ljh18817424778@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Kai-Lin Jiang, Xiang-Xiang Wang, Xue-Jiao Liu, Li-Kun Guo, Qing-Ling Jia, Ke-Ming Yang, Jiang-Hong Ling, Department of Gastroenterology, Shuguang Hospital, Shanghai 200021, China
Yong-Qi Chen, Department of Pathology, Shuguang Hospital, Shanghai 200021, China
Co-first authors: Kai-Lin Jiang and Xiang-Xiang Wang.
Author contributions: Jiang KL and Ling JH contributed to the conceptualization; Wang XX was involved in the methodology, literature searching, and data extraction; Liu XJ and Chen YQ are responsible for the software; Jia QL and Yang KM contributed to the formal analysis; Jiang KL and Liu XJ wrote the manuscript; Jiang KL contributed to the figure and table; Ling JH participated in the funding acquisition; and all authors have read and agreed to the published version of the manuscript.
Supported byNational Natural Science Foundation of China, No. 82174309 and No. 81973774; National Administration of Traditional Chinese Medicine: 2019 Project of Building Evidence-Based Practice Capacity for TCM, No. 2019XZZX-XH013; and Shuguang Hospital Siming Foundation Research Special Project, No. SGKJ-202304.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang-Hong Ling, PhD, Professor, Department of Gastroenterology, Shuguang Hospital, No. 185 Pu’an Road, Huangpu District, Shanghai 200021, China. ljh18817424778@163.com
Received: October 2, 2023 Peer-review started: October 2, 2023 First decision: January 5, 2024 Revised: January 18, 2024 Accepted: February 29, 2024 Article in press: February 29, 2024 Published online: April 15, 2024 Processing time: 191 Days and 10.5 Hours
ARTICLE HIGHLIGHTS
Research background
The study explores success rate of human-derived gastric cancer organoids (GCOs) culture, highlighting their widespread use in research and factors that influence culture success rate.
Research motivation
The study aims to review the success rates of GCO culture through a meta-analysis and explore the factors affecting these rates, addressing a significant gap in gastric cancer (GC) research.
Research objectives
The primary objective is to systematically review and meta-analyze the success rates of GCOs, identifying influencing factors that can guide future research in this area.
Research methods
The study employed a systematic review and meta-analysis, utilizing databases like PubMed, Web of Science, and EMBASE for data collection, and STATA 17.0 for meta-analysis.
Research results
The research revealed a pooled success rate of 66.6% for GCO culture, influenced by factors like sex, tissue source, and cancer stage. The study also highlighted the variation in success rates based on different methodological approaches.
Research conclusions
The study proposes new insights into the factors influencing GCO culture success, suggesting that these factors significantly affect research outcomes in GC.
Research perspectives
Future research is directed towards improving GCO culture techniques, taking into account the identified influencing factors, and potentially advancing GC research and personalized medicine.
