Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1200
Peer-review started: February 4, 2023
First decision: March 21, 2023
Revised: March 28, 2023
Accepted: May 6, 2023
Article in press: May 6, 2023
Published online: July 15, 2023
Processing time: 157 Days and 19.8 Hours
Gastric cancer (GC) is one of the most common digestive system cancers with high mortality rates worldwide.
Cuproptosis is strongly correlated with the biological behaviour of malignant tumour cells and no previous studies have estimated the relationship between cuproptosis related genes (CRGs) and the progression of GC.
Our study aims to offer new insights to predict GC prognosis and provide multiple therapeutic targets for future therapy about CRGs.
We collected data from several public data portals and systematically estimated the expression level and prognostic values of CRGs in GC samples and related mechanisms using public databases and bioinformatics.
We found that FDX1, LIAS, and MTF1 were differentially expressed in GC samples and exhibited important prognostic significance. We constructed a nomogram model for overall survival and disease-specific survival prediction and validated it via calibration plots. Mechanistically, immune cell infiltration and DNA methylation prominently affected the survival time of GC patients. Moreover, protein-protein interaction network, KEGG pathway and gene ontology enrichment analyses demonstrated that FDX1, LIAS, MTF1 and related proteins played key roles in the tricarboxylic acid cycle and cuprotosis. Top 10 perturbagens were filtered as well.
Our findings suggested that FDX1, LIAS, and MTF1 had important implications for the prediction of OS and DSS in GC patients, which were associated with various immune cell infiltrations, providing novel insights into therapeutic strategies for GC patients.
Considerable effort needs to be expended in exploring the therapeutic strategies via CRGs in GC.