Published online Oct 15, 2020. doi: 10.4251/wjgo.v12.i10.1177
Peer-review started: July 20, 2020
First decision: August 9, 2020
Revised: August 18, 2020
Accepted: September 14, 2020
Article in press: September 14, 2020
Published online: October 15, 2020
Processing time: 86 Days and 2.6 Hours
Methods such as hepatectomy, ablation therapy, interventional therapy, and systemic chemotherapy improve the quality of life and prolong survival. Through the comparison of different prognostic factors and treatment plans, it is hoped that a more reasonable treatment plan will be obtained, which will provide evidence-based basis for clinical treatment.
This study analyzed the prognosis of different treatment methods, combining pathological characteristics and prognostic factors to formulate the most suitable treatment plan for patients.
Through the comparison of prognostic factors and treatment rules, it is hoped that a more reasonable treatment plan will be obtained, which will provide evidence-based basis for clinical treatment.
The clinicopathological data and postoperative survival of four groups of colorectal cancer patients with liver metastases (surgical resection group, ablation treatment group, interventional treatment group, and chemotherapy alone group) were retrospectively analyzed. The survival analysis was performed by the Kaplan-Meier method, and multivariate Cox proportional hazard regression model was used for analysis.
The Cox proportional hazards model showed that the following factors are independent factors affecting prognosis: The degree of tumor differentiation, the number of metastases, the size of metastases, and whether the metastases are close to great vessels. The effect of surgical treatment was better than that of drugs, intervention, or ablation alone.
Patients with a low degree of primary tumor differentiation, multiple liver metastases (number of tumors > 4), and maximum diameter of liver metastases > 5 cm have a poor prognosis. Surgical treatment is the first choice for liver metastases, especially when liver metastases are close to great vessels.
Radical surgery is the first choice for the treatment of patients with liver metastases from colorectal cancer. At the same time, multidisciplinary diagnosis and treatment should be discussed and combined with the actual situation to develop the most suitable treatment plan for the patient.