Published online Jan 15, 2016. doi: 10.4251/wjgo.v8.i1.99
Peer-review started: October 14, 2015
First decision: October 15, 2015
Revised: October 20, 2015
Accepted: December 3, 2015
Article in press: December 4, 2015
Published online: January 15, 2016
Processing time: 260 Days and 13.7 Hours
Over the past couple of decades considerable progress has been made in the management of metastatic colorectal cancers (mCRC) leading to a significant improvement in five-year survival. Although part of this success has been rightly attributed to aggressive surgical management and advances in other adjunct treatments, our understanding of the pathogenesis of cancer and emergence of newer molecular targets for colon cancer has created a powerful impact. In this review article we will discuss various targeted therapies in the management of mCRC. Newer agents on the horizon soon to be incorporated in clinical practice will be briefly reviewed as well.
Core tip: This article reviews the novel agents in the management of metastatic colorectal cancer. The core principles and the evidence behind the use of these agents are discussed. Clinically relevant features are highlighted to help the health care provider involved in the care of metastatic colorectal cancer patients.