Immune cell interplay in colorectal cancer prognosis

doi:10.4251/wjgo.v7.i10.221

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Oct 15, 2015 (publication date) through Mar 15, 2026

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Oct 15, 2015; 7(10): 221-232
Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.221

Immune cell interplay in colorectal cancer prognosis

Samuel E Norton, Kirsten A Ward-Hartstonge, Edward S Taylor, Roslyn A Kemp

Samuel E Norton, Kirsten A Ward-Hartstonge, Edward S Taylor, Roslyn A Kemp, Department of Microbiology and Immunology, University of Otago, Dunedin 9010, New Zealand

Author contributions: Norton SE and Ward-Hartstonge KA contributed equally to this work; all authors contributed to conceptualisation and wrote the paper.

Conflict-of-interest statement: No potential conflicts of interest relevant to this article exist.

Correspondence to: Roslyn A Kemp, PhD, Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9010, New Zealand. roslyn.kemp@otago.ac.nz

Telephone: +64-3-4797708 Fax: +64-3-4798540

Received: April 28, 2015
Peer-review started: May 7, 2015
First decision: June 2, 2015
Revised: June 12, 2015
Accepted: August 25, 2015
Article in press: August 28, 2015
Published online: October 15, 2015
Processing time: 173 Days and 20.7 Hours

Abstract

The immune response to colorectal cancer has proven to be a reliable measure of patient outcome in several studies. However, the complexity of the immune response in this disease is not well understood, particularly the interactions between tumour-associated cells and cells of the innate and adaptive immune system. This review will discuss the relationship between cancer associated fibroblasts and macrophages, as well as between macrophages and T cells, and demonstrate how each population may support or prevent tumour growth in a different immune environment.

Keywords: Colorectal cancer neoplasms; Fibroblasts; Immune system processes; Macrophages; T lymphocytes

Core tip: The outcome of patients with colorectal cancer is influenced by the complex local immune system. Understanding how multiple relationships between immune cells may affect tumour growth or elimination will be key in designing new therapies to treat this disease.