Tian Y, Liu GQ, Li CF, Tian QM, Qiao S. Colossal well-differentiated liposarcoma of the small bowel mesentery: A case report. World J Gastrointest Oncol 2026; 18(1): 114648 [DOI: 10.4251/wjgo.v18.i1.114648]
Corresponding Author of This Article
Song Qiao, MD, Department of Gastrointestinal Surgery, Tongren City People’s Hospital, No. 120 Middle Section of Taoyuan Avenue, Chuandong Education Park, Tongren 554300, Guizhou Province, China. 13985850520@163.com
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Surgery
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Case Report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 15, 2026 (publication date) through Jan 12, 2026
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World Journal of Gastrointestinal Oncology
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1948-5204
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Tian Y, Liu GQ, Li CF, Tian QM, Qiao S. Colossal well-differentiated liposarcoma of the small bowel mesentery: A case report. World J Gastrointest Oncol 2026; 18(1): 114648 [DOI: 10.4251/wjgo.v18.i1.114648]
World J Gastrointest Oncol. Jan 15, 2026; 18(1): 114648 Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.114648
Colossal well-differentiated liposarcoma of the small bowel mesentery: A case report
Yong Tian, Guo-Qin Liu, Chuan-Fang Li, Qing-Ming Tian, Song Qiao
Yong Tian, Chuan-Fang Li, Qing-Ming Tian, Song Qiao, Department of Gastrointestinal Surgery, Tongren City People’s Hospital, Tongren 554300, Guizhou Province, China
Guo-Qin Liu, Hemodialysis Center, Tongren Municipal Maternal and Child Health Hospital, Tongren 554300, Guizhou Province, China
Co-first authors: Yong Tian and Guo-Qin Liu.
Co-corresponding authors: Qing-Ming Tian and Song Qiao.
Author contributions: Tian Y and Liu GQ contribute equally to this study as co-first authors; Tian QM and Qiao S contribute equally to this study as co-corresponding authors; Tian Y consulted the literature and wrote the manuscript; Liu GQ studied the literature and made pictures; Li CF, Tian QM and Qiao S operated on the patient and had the idea for this case report; Qiao S checked the manuscript and made the corrections; all authors read and approved the final manuscript.
Informed consent statement: The patient provided a written informed consent form.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Song Qiao, MD, Department of Gastrointestinal Surgery, Tongren City People’s Hospital, No. 120 Middle Section of Taoyuan Avenue, Chuandong Education Park, Tongren 554300, Guizhou Province, China. 13985850520@163.com
Received: September 25, 2025 Revised: October 31, 2025 Accepted: December 4, 2025 Published online: January 15, 2026 Processing time: 109 Days and 9.6 Hours
Abstract
BACKGROUND
Well-differentiated small bowel mesenteric liposarcoma (LPS) is rare, with high malignancy, poor prognosis, and high preponderance to local recurrence.
CASE SUMMARY
Here we described a 71-year-old male, who complains of persistent abdominal distension for a month. The clinical manifestation is a huge abdominal mass occupying almost the entire abdomen. Physical examination indicated palpable massive mass in the abdomen, hard texture, indefinable boundary, poor mobility. The abdominal enhanced computed tomography at another hospital scan showed multiple abdominal masses originating from the small bowel mesentery. Abdominal and pelvic magnetic resonance imaging at our hospital showed multiple masses in the abdominal and pelvic cavities, indicating that the tumor originated from the mesentery or peritoneum. Results of exploratory laparotomy indicated that the tremendous mass primarily results from the mesentery of the small intestine, occupying the entire abdominal cavity in a polymorphic and lobulated shape. The patient underwent complete surgical resection of the tumor, and the weight of the tumor was approximately 11 kg. The histopathological examination of the resected specimens confirmed the diagnosis of well-differentiated LPS of the small bowel mesentery.
CONCLUSION
Completed surgical resection was cornerstone, and histopathological and molecular confirmations were crucial. The necessity of adjuvant therapy should be phrased as a potential consideration to improve patient’s survival time.
Core Tip: Well-differentiated small bowel mesenteric liposarcoma (LPS) is rare, with high malignancy, poor prognosis, and high preponderance to local recurrence. The patient underwent complete surgical resection of the tumor, and the weight of the tumor was approximately 11 kg. Both histopathological and fluorescence in situ hybridization examination confirmed that MDM2 amplification, and the small intestine mesenteric well-differentiated LPS was accurate diagnosed.
