Cai Z, Dai WD, Cai XW. Prognostic impact of inflammatory and nutritional markers in colorectal cancer patients with peritoneal metastasis. World J Gastrointest Oncol 2025; 17(6): 100010 [PMID: 40547170 DOI: 10.4251/wjgo.v17.i6.100010]
Corresponding Author of This Article
Xiong-Wei Cai, PhD, Department of Gynecology, Chongqing Health Center for Women and Children, Women and Children’s Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 410013, China. xiongweicai@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jun 15, 2025; 17(6): 100010 Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.100010
Prognostic impact of inflammatory and nutritional markers in colorectal cancer patients with peritoneal metastasis
Zhao Cai, Wei-De Dai, Xiong-Wei Cai
Zhao Cai, Wei-De Dai, Department of Ultrasound, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100005, China
Xiong-Wei Cai, Department of Gynecology, Chongqing Health Center for Women and Children, Women and Children’s Hospital of Chongqing Medical University, Chongqing 410013, China
Author contributions: Cai Z contributed to the writing and review of literature; Cai Z, Dai WD, and Cai XW contributed to editing the manuscript; Cai Z, Dai WD, and Cai XW contributed to the overall conception and outline design of the manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiong-Wei Cai, PhD, Department of Gynecology, Chongqing Health Center for Women and Children, Women and Children’s Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 410013, China. xiongweicai@126.com
Received: August 7, 2024 Revised: January 23, 2025 Accepted: February 11, 2025 Published online: June 15, 2025 Processing time: 310 Days and 2.4 Hours
Abstract
In this article, we critically appraise the study by Wu et al, which investigated the prognostic value of preoperative inflammatory and nutritional markers in colorectal cancer patients with peritoneal metastasis. This retrospective cohort study included 133 patients. The findings indicate that patients with high neutrophil-to-lymphocyte ratios (NLRs) or lower hemoglobin (Hb) levels have significantly shorter overall survival (OS) than those with lower NLRs or normal Hb levels, respectively. Furthermore, age, carbohydrate antigen 199 levels, the NLR, Hb, and the peritoneal cancer index were identified as independent prognostic factors for OS. A nomogram was subsequently developed, demonstrating its ability to accurately predict the OS of colorectal cancer patients with peritoneal metastasis. This study introduces a potentially valuable prognostic tool for these patients. However, further validation in multicenter cohorts is needed to confirm its clinical applicability, to assess its limitations, and to elucidate the underlying mechanism of these identified biomarkers.
Core Tip: Colorectal cancer (CRC) remains a major global health challenge, with metastasis posing a critical obstacle to treatment and patient management. Preoperative inflammatory and nutritional markers have been identified as independent prognostic markers for CRC patients with peritoneal metastasis. When combined with age, carbohydrate antigen 199 levels, and the peritoneal cancer index, these markers provide a reliable method for predicting overall survival. This combination offers a promising tool for predicting the prognosis and guiding the treatment of CRC with peritoneal metastasis.
