Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3436-3444
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3436
Analysis of vascular thrombus and clinicopathological factors in prognosis of gastric cancer: A retrospective cohort study
Guo-Yue Chen, Ping Ren, Zhen Gao, Hao-Ming Yang, Yan Jiao
Guo-Yue Chen, Ping Ren, Zhen Gao, Yan Jiao, Department of Radiology, Jinan Central Hospital, Jinan 250013, Shandong Province, China
Hao-Ming Yang, Department of Gastrointestinal Surgery, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China
Author contributions: Chen GY wrote the manuscript; Ren P, Gao Z and Yang HM collected the data and Jiao Y guided the study. All authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Jiangsu Provincial People's Hospital.
Informed consent statement: This study has obtained the informed consent of the patients and their families.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: Subject to patient privacy and data security, research data may be made available to qualified researchers upon reasonable request for scientific research and academic exchange.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Jiao, MD, Doctor, Department of Radiology, Jinan Central Hospital, No. 105 Jiefang Road, Lixia District, Jinan 250013, Shandong Province, China. lajiao221717@163.com
Received: February 26, 2024
Revised: June 25, 2024
Accepted: July 8, 2024
Published online: August 15, 2024
Processing time: 163 Days and 23 Hours
Abstract
BACKGROUND

Gastric cancer (GC) is one of the most common malignant tumors in the world, and its prognosis is closely related to many factors. In recent years, the incidence of vascular thrombosis in patients with GC has gradually attracted increasing attention, and studies have shown that it may have a significant impact on the survival rate and prognosis of patients. However, the specific mechanism underlying the association between vascular thrombosis and the prognosis of patients with GC remains unclear.

AIM

To analyze the relationships between vascular cancer support and other clinicopathological factors and their influence on the prognosis of patients with GC.

METHODS

This study retrospectively analyzed the clinicopathological data of 621 patients with GC and divided them into a positive group and a negative group according to the presence or absence of a vascular thrombus. The difference in the 5-year cumulative survival rate between the two groups was compared, and the relationships between vascular cancer thrombus and other clinicopathological factors and their influence on the prognosis of patients with GC were analyzed.

RESULTS

Among 621 patients with GC, the incidence of vascular thrombi was 31.7% (197 patients). Binary logistic regression analysis revealed that the degree of tumor differentiation, depth of invasion, and extent of lymph node metastasis were independent influencing factors for the occurrence of vascular thrombi in GC patients (P < 0.01). The trend of the χ2 test showed that the degree of differentiation, depth of invasion, and extent of lymph node metastasis were linearly correlated with the percentage of vascular thrombi in GC patients (P < 0.01), and the correlation between lymph node metastasis and vascular thrombi was more significant (r = 0.387). Univariate analysis revealed that the 5-year cumulative survival rate of the positive group was significantly lower than that of the negative group (46.7% vs 73.3%, P < 0.01). Multivariate analysis revealed that age, tumor diameter, TNM stage, and vascular thrombus were independent risk factors for the prognosis of GC patients (all P < 0.05). Further stratified analysis revealed that the 5-year cumulative survival rate of stage III GC patients in the thrombolase-positive group was significantly lower than that in the thrombolase-negative group (36.1% vs 51.4%; P < 0.05).

CONCLUSION

Vascular cancer status is an independent risk factor affecting the prognosis of patients with GC. The combination of vascular cancer suppositories and TNM staging can better judge the prognosis of patients with GC and guide more reasonable treatment.

Keywords: Vascular cancer thrombus; Gastric cancer; Survival prognosis; TNM staging; Retrospective study

Core Tip: The relationships between vascular thrombosis and survival rate, recurrence rate and other prognostic indices were investigated by statistical analysis. The aim of this study was to summarize the potential mechanism by which vascular thrombosis influences the prognosis of patients with gastric cancer and to provide data and a theoretical basis for clinical treatment decision-making and individualized treatment strategies.