Christodoulidis G, Agko SE, Kouliou MN, Koumarelas KE. Unveiling the clinicopathological enigma of crawling-type gastric adenocarcinoma. World J Gastrointest Oncol 2024; 16(11): 4321-4325 [PMID: 39554752 DOI: 10.4251/wjgo.v16.i11.4321]
Corresponding Author of This Article
Grigorios Christodoulidis, MD, PhD, Academic Editor, Department of General Surgery, University Hospital of Larissa, University of Thessaly, Biopolis Campus, Mezourlo, Larissa 41110, Greece. gregsurg@yahoo.gr
Research Domain of This Article
Oncology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Nov 15, 2024; 16(11): 4321-4325 Published online Nov 15, 2024. doi: 10.4251/wjgo.v16.i11.4321
Unveiling the clinicopathological enigma of crawling-type gastric adenocarcinoma
Grigorios Christodoulidis, Sara E Agko, Marina N Kouliou, Konstantinos E Koumarelas
Grigorios Christodoulidis, Marina N Kouliou, Konstantinos E Koumarelas, Department of General Surgery, University Hospital of Larissa, University of Thessaly, Biopolis Campus, Larissa 41110, Greece
Sara E Agko, Department of Orthopedic, University Hospital of Larissa, Larissa 41110, Greece
Author contributions: Christodoulidis G, Agko SE, Koumarelas KE and Kouliou MN contributed to this paper; Christodoulidis G designed the overall concept and outline of the manuscript; Christodoulidis G, Agko SE, Koumarelas KE and Kouliou MN contributed to the discussion and design of the manuscript; Christodoulidis G, Agko SE, Koumarelas KE and Kouliou MN contributed to the writing, editing the manuscript, and review of the literature.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Grigorios Christodoulidis, MD, PhD, Academic Editor, Department of General Surgery, University Hospital of Larissa, University of Thessaly, Biopolis Campus, Mezourlo, Larissa 41110, Greece. gregsurg@yahoo.gr
Received: March 23, 2024 Revised: May 14, 2024 Accepted: June 11, 2024 Published online: November 15, 2024 Processing time: 215 Days and 15.2 Hours
Abstract
In this editorial we comment on the article by Xu et al. Gastric adenocarcinoma (GA) is a malignancy which arises from the gastric mucosa and encompasses heterogenous tumors with varying characteristics. There are two main classifications: Lauren’s and the World Health Organization distinguishing the diverse types of GA depending on clinical, genetic, morphological and epidemiological features. “Crawling-type” adenocarcinoma (CRA) is a subtype characterized by irregularly fused glands with low-grade cellular atypia. Moreover, CRA represents differentiated tumor cells resembling intestinal metaplasia which results in misdiagnosis. The diagnosis is of utmost importance, as well as the subclassification and thorough pathological assessment. With regard to the symptoms of GA, these depend on the stage of the disease. Diagnostic methods play a crucial role in assessing the extent of the tumor and the stage of the disease. Nevertheless, early detection of CRA remains challenging due to its histological features. In summary, CRA is a distinct type of GA with particular clinicopathological and histological characteristics. Despite its significance, it not distinguished as a subtype, resulting in diagnostic challenges. Diagnosis is based on careful observation and thorough biopsy analysis, indicating the importance of comprehensive pathological assessment.
Core Tip: Crawling-type adenocarcinoma has specific features, such as irregularly fused glands and low-grade cellular atypia, resembling intestinal metaplasia. Given this, precise attention to its histological characteristics is crucial when diagnosing “crawling-type” adenocarcinoma (CRA). Early detection of CRA is challenging which leads to the importance of the detection of molecular markers and thorough biopsy analysis for accurate classification and clinical management strategies.
