Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.368
Peer-review started: November 19, 2022
First decision: December 25, 2022
Revised: January 3, 2023
Accepted: February 2, 2023
Article in press: February 2, 2023
Published online: February 15, 2023
Processing time: 87 Days and 13.3 Hours
The coronavirus disease 2019 (COVID-19) pandemic has become a global burden, further exacerbating the occurrence of risk events in cancer patients. The high risk of death from pancreatic cancer makes it one of the most lethal malignancies. Recently, it was reported in the World Journal of Gastrointestinal Oncology that COVID-19 influences pancreatic cancer progression via the lung–gut–pancreatic axis, and the authors provided insights into the intrinsic crosstalk mechanisms in which the gut microbiota is involved, the characteristics and effects of inflammatory factors, and immunotherapeutic strategies for treating both diseases. Here, we review the latest cutting-edge researches in the field of the lung-gut-pancreatic axis and discuss future perspectives to address the severe survival challenges posed by the COVID-19 pandemic in patients with pancreatic cancer.
Core Tip: The coronavirus disease 2019 (COVID-19) pandemic has become a global burden, further exacerbating the occurrence of mortality risk events in patients with pancreatic cancer. The aim of this new article is to highlight the need for lung-gut-pancreatic axis-based studies with a focus on intra-axis microbiota crosstalk and potential mechanisms of association to address the severe survival challenges posed by the COVID-19 pandemic in patients with pancreatic cancer.