Liu J, Huang BJ, Ding FF, Tang FT, Li YM. Synchronous occurrence of gastric cancer and gastrointestinal stromal tumor: A case report and review of the literature. World J Gastrointest Oncol 2023; 15(10): 1807-1822 [PMID: 37969409 DOI: 10.4251/wjgo.v15.i10.1807]
Corresponding Author of This Article
Yu-Min Li, MD, PhD, Chief Physician, Professor, Surgeon, Surgical Oncologist, Department of General Surgery, Lanzhou University Second Hospital, No. 80 Cuiyingmen, Lanzhou 730030, Gansu Province, China. liym@lzu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Oct 15, 2023; 15(10): 1807-1822 Published online Oct 15, 2023. doi: 10.4251/wjgo.v15.i10.1807
Synchronous occurrence of gastric cancer and gastrointestinal stromal tumor: A case report and review of the literature
Jie Liu, Bin-Jie Huang, Fei-Fei Ding, Fu-Tian Tang, Yu-Min Li
Jie Liu, Bin-Jie Huang, Fei-Fei Ding, Fu-Tian Tang, Yu-Min Li, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China
Jie Liu, Bin-Jie Huang, Fei-Fei Ding, Fu-Tian Tang, Yu-Min Li, Key Laboratory of the Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China
Author contributions: Liu J performed data collection, statistical analysis, literature collection, and manuscript writing; Huang BJ, Tang FT, and Ding FF participated in the investigation and revision; Li YM designed, supervised, and guided this study; and all authors contributed to the article and approved the submitted version.
Supported bythe Fundamental Research Funds for the Central Universities, No. lzujbky-2022-sp08.
Informed consent statement: Informed written or verbal consent were obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Min Li, MD, PhD, Chief Physician, Professor, Surgeon, Surgical Oncologist, Department of General Surgery, Lanzhou University Second Hospital, No. 80 Cuiyingmen, Lanzhou 730030, Gansu Province, China. liym@lzu.edu.cn
Received: May 31, 2023 Peer-review started: May 31, 2023 First decision: July 31, 2023 Revised: August 20, 2023 Accepted: September 14, 2023 Article in press: September 14, 2023 Published online: October 15, 2023 Processing time: 131 Days and 17.8 Hours
Abstract
BACKGROUND
To evaluate the clinicopathological features and prognosis of gastric cancer (GC) occurring synchronously with gastrointestinal stromal tumor (GIST).
CASE SUMMARY
We report 19 patients with concurrent GC and GIST (17 male and 2 female, median age 62 years). GC was most often located in the lower third of the stomach. GIST was diagnosed preoperatively in four patients. GIST was most often located in the gastric body (n = 8, 42%). The most common growth pattern in GIST was extraluminal (n = 12, 63%). The positive expression rates of CD117 and CD34 in GIST were 100% and 95%, respectively. Most patients with GIST (n = 17, 89%) were very low or low risk. There was no recurrence of GIST during follow-up. The 3-year cumulative survival rate was 73.9%, and the 5-year cumulative survival rate was 59.2%. The combined analysis of this study and literature reports (47 reports, 157 patients) found that GC and GIST were usually located in the lower third (42%) and middle third (51%) of the stomach. GC was usually early (stage I: 42%), poorly differentiated (42%) intestinal-type adenocarcinoma (51%). GISTs were primarily small in diameter (median: 1.2 cm) and very low or low risk (89%).
CONCLUSION
Synchronous GC and GIST may not be rare. They have specific clinicopathological characteristics, and may have mutual inhibition in pathogenesis and progression.
Core Tip: We conclude that there are specific clinicopathological features in gastric cancer (GC) and gastrointestinal stromal tumor (GIST), as is often seen in older men; GC is usually a poorly differentiated enterotype early adenocarcinoma located in the lower third of the stomach. GIST is usually small in diameter, low or very low risk, and located in the body of the stomach. We hypothesized that GC and GIST might be affected by the same unknown carcinogen, leading to the simultaneous proliferation of epithelial and mesenchymal cells. GC and GIST may inhibit each other in the occurrence and development of the disease.
