Published online Aug 15, 2022. doi: 10.4251/wjgo.v14.i8.1597
Peer-review started: April 1, 2022
First decision: May 1, 2022
Revised: May 1, 2022
Accepted: July 16, 2022
Article in press: July 16, 2022
Published online: August 15, 2022
Processing time: 131 Days and 5.4 Hours
The original article by Yuichi et al explored whether the Japan Narrow-Band Imaging Expert Team classification and the pit pattern classification are suitable for diagnosing neoplastic lesions in patients with ulcerative colitis. In this letter, we offer some other perspectives. Risk factors for colorectal tumors include type 2 diabetes. Among genetic factors, the deletion or mutation of some genes, such as the p53 gene, can lead to colorectal tumors. There are significant gender differences in the occurrence and development of colorectal tumors. Some non-genetic factors, such as smoking, are also associated with the development of colorectal tumors. These all suggest that colorectal tumors are not only caused by ulcerative colitis, and we suggest further exploration and differentiation between colitis and colorectal tumors.
Core Tip: Among genetic factors, the deletion or mutation of some tumor suppressor genes can lead to colorectal tumors. Non-genetic factors are also associated with the development of colorectal tumors. The underlying disease can be a risk factor for colorectal tumors. There are significant gender differences in the occurrence and development of colorectal tumors. These all suggest that colorectal tumors are not only caused by ulcerative colitis, and we suggest further exploration and differentiation between colitis and colorectal tumors.