Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.758
Peer-review started: January 22, 2021
First decision: February 24, 2021
Revised: February 27, 2021
Accepted: June 23, 2021
Article in press: June 23, 2021
Published online: August 15, 2021
Processing time: 203 Days and 21.7 Hours
Gastrointestinal (GI) cancer remains one of the most prevalent cancers in the world. The occurrence and progression of GI cancer involve multiple events. Metabolic reprogramming is one of the hallmarks of cancer and is intricately related to tumorigenesis. Many metabolic genes are involved in the occurrence and development of GI cancer. Research approaches combining tumor genomics and metabolomics are more likely to provide deeper insights into this field. In this paper, we review the roles of metabolism-associated genes, especially those involved in the regulation pathways, in the occurrence and progression of GI cancer. We provide the latest progress and future prospect into the different molecular mechanisms of metabolism-associated genes involved in the occurrence and development of GI cancer.
Core Tip: Metabolic reprogramming is one of the hallmarks of cancer and is intricately related to tumorigenesis. Many metabolic genes are involved in the occurrence and development of gastrointestinal (GI) cancer. This state-of-the-art review comprehensively describes the latest progress and prospects into the different molecular mechanisms of metabolism-associated genes involved in the occurrence and development of GI cancer.