Effect of family history on detection of adenomas and sessile serrated lesions in individuals aged 40s

Table 1 Patient characteristics, n/%

	All	40s	50s	60s	70s
Number	10248	2317	3564	2540	1827
Mean age (years)	57.1	45.2	54.6	64.0	74.0
Male sex	44.8	43.0	44.1	46.2	46.3
Family history	8.2	6.2	7.5	9.7	8.5
Positive FIT	13.2	18.9	14.1	10.3	10.1
Index colonoscopy	21.0	34.7	22.5	14.6	9.8
ADR	55.1	38.8	54.7	61.9	67.0
ASDR	59.0	44.5	58.5	65.2	69.7

FIT: Fecal immunochemical test; ADR: Adenoma detection rate; ASDR: Adenoma plus sessile serrated lesion detection rate.

Table 2 The effect of family history on adenoma detection rates based on age, %

	Family history (-)	Family history (+)	Odds ratio	95%CI	P value1
40s	38.2	47.6	1.59	1.13-2.25	0.008
50s	54.9	52.4	0.96	0.74-1.23	0.73
60s	61.7	63.4	1.09	0.83-1.44	0.52
70s	66.6	70.1	1.19	0.85-1.66	0.31

¹P value was calculated using a binomial regression model and adjusted by sex and fecal immune test results.

CI: Confidence interval.

Table 3 The effect of family history on adenoma plus sessile serrated lesion detection rates based on age, %

	Family history (-)	Family history (+)	Odds ratio	95%CI	P value1
40s	43.7	58.0	1.92	1.36-2.71	< 0.001
50s	58.5	58.7	1.06	0.83-1.37	0.63
60s	64.9	68.3	1.19	0.90-1.59	0.22
70s	69.6	70.1	1.03	0.74-1.44	0.84

¹P value was calculated using a binomial regression model and adjusted by sex and fecal immune test results.

CI: Confidence interval.