Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Oct 16, 2025; 17(10): 109380
Published online Oct 16, 2025. doi: 10.4253/wjge.v17.i10.109380
Published online Oct 16, 2025. doi: 10.4253/wjge.v17.i10.109380
Effect of family history on detection of adenomas and sessile serrated lesions in individuals aged 40s
Osamu Toyoshima, Toshihiro Nishizawa, Hiroki Asano, Mari Mizutani, Takeshi Uozumi, Ai Fujimoto, Masaya Sano, Shuntaro Yoshida, Keisuke Hata, Department of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan
Toshihiro Nishizawa, Hirotoshi Ebinuma, Department of Gastroenterology and Hepatology, International University of Health and Welfare Narita Hospital, Narita 286-8520, Japan
Hiroki Asano, Department of Gastroenterology, The University of Tokyo, Tokyo 113-8655, Japan
Mari Mizutani, Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo 160-8582, Japan
Takeshi Uozumi, Endoscopy Division, National Cancer Center Hospital, Tokyo, 104-0045, Japan
Ai Fujimoto, Department of Gastroenterology and Hepatology, Faculty of Medicine, Toho University, Tokyo, 143-8540, Japan
Masaya Sano, Department of Internal Medicine, Tokai University School of Medicine, Isehara 259-1193, Japan
Keisuke Hata, Department of Gastroenterology, Nihonbashi Muromachi Mitsui Tower Midtown Clinic, Tokyo 103-0022, Japan
Co-first authors: Osamu Toyoshima and Toshihiro Nishizawa.
Author contributions: Toyoshima O, Nishizawa T, Asano H, Mizutani M, Uozumi T, Fujimoto A, Sano M, and Yoshida S contributed to endoscopic diagnosis; Toyoshima O contributed to statistical analysis; Nishizawa T contributed to literature search and article writing; Hata K contributed to patient recruitment; Ebinuma H contributed to final scrutiny of the study. Toyoshima O and Nishizawa T contributed equally to this manuscript and are co-first authors. All authors contributed to the study design, article review, and final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of the Certified Institutional Review Board of the Yoyogi Mental Clinic (Approval No. RKK227).
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: The authors declare no conflicts of interest associated with this manuscript.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Osamu Toyoshima, MD, Department of Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo 157-0066, Japan. t@ichou.com
Received: May 9, 2025
Revised: June 12, 2025
Accepted: September 2, 2025
Published online: October 16, 2025
Processing time: 160 Days and 20 Hours
Revised: June 12, 2025
Accepted: September 2, 2025
Published online: October 16, 2025
Processing time: 160 Days and 20 Hours
Core Tip
Core Tip: Participants in their 40s with a family history showed a high adenoma detection rate (47.6%) when expert endoscopists performed colonoscopies using the latest endoscopic system. There was a significant increase in the adenoma detection rate in those with a family history compared to those without, among participants aged 40-49 years.