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World J Gastrointest Endosc. Apr 16, 2026; 18(4): 115366
Published online Apr 16, 2026. doi: 10.4253/wjge.v18.i4.115366
Published online Apr 16, 2026. doi: 10.4253/wjge.v18.i4.115366
Fecal microbiota transplantation for indolent T-cell lymphoproliferative disorder of gastrointestinal tract: A case report and review of literature
Yi-Ming Yu, Ye Chen, Bing-Yun Lu, Department of Gastroenterology, Integrative Microecology Clinical Center, Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease, Shenzhen Clinical Research Center for Digestive Disease, Shenzhen Technology Research Center of Gut Microbiota Transplantation, Shenzhen Hospital, Southern Medical University, Shenzhen 518101, Guangdong Province, China
Jun Huang, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: Yu YM was responsible for the drafting and critical revision of the manuscript; Huang J was responsible for patient follow-up and the organization of clinical data; Chen Y and Lu BY were responsible for the diagnosis, clinical management of the patient, and participation in multidisciplinary discussions; Lu BY additionally supervised and approved the final manuscript.
Supported by the Shenzhen Medical Research Special Fund Project Plan, No. C2401027; Research Foundation of Shenzhen Hospital of Southern Medical University, No. PY2022YM06; and Shenzhen Special Fund for Sustainable Development, No. KCXFZ20211020163558024.
Informed consent statement: The authors confirm that written informed consent was obtained from the patient.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Bing-Yun Lu, MD, PhD, Professor, Department of Gastroenterology, Integrative Microecology Clinical Center, Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease, Shenzhen Clinical Research Center for Digestive Disease, Shenzhen Technology Research Center of Gut Microbiota Transplantation, Shenzhen Hospital, Southern Medical University, No. 1333 Xinhu Road, Bao’an District, Shenzhen 518101, Guangdong Province, China. lubingyun_smu@163.com
Received: October 17, 2025
Revised: December 16, 2025
Accepted: February 3, 2026
Published online: April 16, 2026
Processing time: 180 Days and 15 Hours
Revised: December 16, 2025
Accepted: February 3, 2026
Published online: April 16, 2026
Processing time: 180 Days and 15 Hours
Core Tip
Core Tip: Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract is frequently misdiagnosed as inflammatory bowel disease, leading to ineffective treatments. This first successful use of fecal microbiota transplantation in a patient with indolent T-cell lymphoproliferative disorder of the gastrointestinal resulted in sustained clinical and endoscopic remission, suggesting that gut dysbiosis may play a key pathogenic role and positioning fecal microbiota transplantation as a novel, microbiota-targeting therapeutic strategy for this rare condition.