Endoscopic retrograde appendicitis therapy: Progress in clinical application

doi:10.4253/wjge.v18.i1.115213

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Jan 16, 2026 (publication date) through Jan 15, 2026

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Endosc. Jan 16, 2026; 18(1): 115213
Published online Jan 16, 2026. doi: 10.4253/wjge.v18.i1.115213

Endoscopic retrograde appendicitis therapy: Progress in clinical application

Li-Qin Luo, Xiao-Ping Xu, Yu-Yang Zhang, Cong Zhou, Ming-Hao Wu

Li-Qin Luo, Xiao-Ping Xu, Yu-Yang Zhang, Cong Zhou, Ming-Hao Wu, Department of Gastroenterology, Hunan Normal University, Hunan Provincial People's Hospital, Changsha 410005, Hunan Province, China

Author contributions: Luo LQ collected data and wrote paper; Xu XP and Wu MH revised paper; Zhang YY and Zhou C collected data; all of the authors read and approved the final version of the manuscript to be published.

Conflict-of-interest statement: We have no conflicts of interest to disclose.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ming-Hao Wu, PhD, Chief Physician, Department of Gastroenterology, Hunan Normal University, Hunan Provincial People's Hospital, No. 61 Jiefang West Road, Furong District, Changsha 410005, Hunan Province, China. wuminghao1976@163.com

Received: October 14, 2025
Revised: October 21, 2025
Accepted: November 26, 2025
Published online: January 16, 2026
Processing time: 96 Days and 11.4 Hours

Core Tip

Core Tip: Endoscopic retrograde appendicitis therapy (ERAT) is a feasible, safe, and economical alternative treatment of acute uncomplicated appendicitis, even complicated appendicitis can be an indication of ERAT and the contraindications to ERAT may just be patients who are unable to routine colonoscopy. The potential risk of ERAT is recurrence due to the retain of appendix, which needs more observation. Further research, such as prospective multicenter randomized clinical trials, is necessary to determine the effectiveness and safety of ERAT in various types of appendicitis.