BPG is committed to discovery and dissemination of knowledge
Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Nov 16, 2025; 17(11): 111243
Published online Nov 16, 2025. doi: 10.4253/wjge.v17.i11.111243
Impact of periampullary diverticulum on the incidence of post-endoscopic retrograde cholangiography pancreatitis
Juan Shu, Yu-Sheng Liao, Yuan-Jie Zhang, Wei-Lai Zhou, Heng Zhang
Juan Shu, Yu-Sheng Liao, Yuan-Jie Zhang, Wei-Lai Zhou, Heng Zhang, Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, China
Co-first authors: Juan Shu and Yu-Sheng Liao.
Author contributions: Shu J and Liao YS performed the research and wrote the manuscript; Zhang YJ performed the research and collected the data; Zhou WL performed the research; Zhang H designed the experiments and revised the manuscript. Shu J and Liao YS are co-first authors of this article, having contributed equally to the research and manuscript preparation.
Institutional review board statement: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of the Central Hospital of Wuhan (Approval No. WHZXKYL2025-135).
Informed consent statement: Informed consent was waived due to the retrospective nature of this research.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Dataset available from the corresponding author. Participants gave informed consent for data sharing.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Heng Zhang, MD, PhD, Chief Physician, Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiangan District, Wuhan 430014, Hubei Province, China. 15802796240@163.com
Received: June 26, 2025
Revised: August 18, 2025
Accepted: September 23, 2025
Published online: November 16, 2025
Processing time: 141 Days and 16 Hours
Core Tip

Core Tip: This study demonstrates that periampullary diverticulum (PAD), particularly type B, shows a significant association with post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). The findings suggest that PAD subtype evaluation may help identify patients with higher likelihood of PEP development. The results indicate potential clinical value of enhanced postoperative monitoring for patients with specific diverticular characteristics and optimization of endoscopic retrograde cholangiopancreatography techniques. These observations contribute to refining PEP prevention strategies and support consideration of individualized procedural approaches.