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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Nov 16, 2025; 17(11): 111107
Published online Nov 16, 2025. doi: 10.4253/wjge.v17.i11.111107
Published online Nov 16, 2025. doi: 10.4253/wjge.v17.i11.111107
Endoscopic biliary drainage with multi-hole self-expandable metallic stent during neoadjuvant chemoradiotherapy in pancreatic cancer
Shohei Asada, Koh Kitagawa, Junichi Hanatani, Yuki Motokawa, Yui Osaki, Tomihiro Iwata, Kosuke Kaji, Hitoshi Yoshiji, Department of Gastroenterology, Nara Medical University, Kashihara 634-8522, Nara, Japan
Akira Mitoro, Division of Endoscopy, Nara Medical University, Kashihara 634-8522, Nara, Japan
Minako Nagai, Masayuki Sho, Department of Surgery, Nara Medical University, Kashihara 634-8522, Nara, Japan
Author contributions: Kitagawa K, Asada S contributed to conceptualization; Hanatani J, Motokawa Y, Osaki Y, Iwata T, Kaji K contributed to data curation; Hanatani J, Motokawa Y, Osaki Y, Iwata T, Kaji K, Nagai M, Mitoro A contributed to investigation; Kitagawa K, Asada S contributed to methodology, project administration, resources, visualization, validation, writing the original draft; Yoshiji H, Sho M contributed to writing review and editing, supervision.
Institutional review board statement: This single-center retrospective study was approved by the Nara Medical University Ethics Committee (4018).
Informed consent statement: This retrospective observational study does not contain identifiable personal information. We published details about the study on our website to allow patients to opt out if they wish.
Conflict-of-interest statement: Koh Kitagawa has received a speaker honorarium from Boston Scientific Japan. Koh Kitagawa has received a consulting fee from M.I. Tech.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Koh Kitagawa, MD, PhD, Department of Gastroenterology, Nara Medical University, 840 Shijou-cho, Kashihara 634-8522, Nara, Japan.
Received: June 24, 2025
Revised: August 10, 2025
Accepted: September 16, 2025
Published online: November 16, 2025
Processing time: 144 Days and 6.8 Hours
Revised: August 10, 2025
Accepted: September 16, 2025
Published online: November 16, 2025
Processing time: 144 Days and 6.8 Hours
Core Tip
Core Tip: We investigated the usefulness of a novel multi-hole self-expandable metallic stent (MH-SEMS) for preoperative biliary drainage during neoadjuvant chemoradiotherapy (NACRT) in patients with pancreatic cancer (PC). We included 14 patients who underwent surgery following biliary drainage using MH-SEMS. Clinical and technical success were achieved in all patients. The median interval between stent placement and surgery was 105 days. Only one patient (7.1%) experienced recurrent biliary obstruction caused by sludge. MH-SEMS placement is a potentially effective treatment option for pre