Published online Apr 16, 2017. doi: 10.4253/wjge.v9.i4.153
Peer-review started: August 30, 2016
First decision: September 27, 2016
Revised: October 23, 2016
Accepted: January 11, 2017
Article in press: January 12, 2017
Published online: April 16, 2017
Processing time: 229 Days and 3.9 Hours
Incidentally detected, sporadic, nonfunctional pancreatic neuroendocrine tumors are increasingly diagnosed on imaging studies performed for unrelated purposes. Although their resection is usually recommended, controversy still exists regarding their optimal management, due to their highly variable and difficult to predict biologic behavior. Recently, several studies and guidelines advocated an expectant management approach in small size, low grade, incidentally diagnosed nonfunctional pancreatic neuroendocrine tumors. The aim of this study is to review and summarize the available literature addressing nonfunctional pancreatic neuroendocrine tumors, with an emphasis on surgical management controversies.
Core tip: Nonfunctional pancreatic neuroendocrine tumors are increasingly diagnosed. Controversy exists regarding their optimal management. Expectant management in small size, low grade, incidentally diagnosed nonfunctional pancreatic neuroendocrine tumors has been suggested as an optional treatment. The aim of this study is to review the available literature addressing nonfunctional pancreatic neuroendocrine tumors, with an emphasis on surgical management controversies.