Li P, Ding RR, Liu J, Zhang MQ, Liu Y. Detachable over-the-scope clip for colon defects in the trans intestinal natural orifice transluminal endoscopic cholecystolithotomy: A case report. World J Gastrointest Endosc 2025; 17(8): 109399 [DOI: 10.4253/wjge.v17.i8.109399]
Corresponding Author of This Article
Yan Liu, Research Fellow, Department of Gastroenterology, The 909th Hospital, School of Medicine, Xiamen University, No. 269 Zhanghua Middle Road, Zhangzhou 363000, Fujian Province, China. 514461566@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Aug 16, 2025; 17(8): 109399 Published online Aug 16, 2025. doi: 10.4253/wjge.v17.i8.109399
Detachable over-the-scope clip for colon defects in the trans intestinal natural orifice transluminal endoscopic cholecystolithotomy: A case report
Pei Li, Rong-Rong Ding, Jiang Liu, Ming-Qing Zhang, Yan Liu
Pei Li, Department of Gastroenterology, The 909th Hospital, School of Medicine, Xiamen University, Fujian Province 363000, Fujian Province, China
Rong-Rong Ding, Jiang Liu, Ming-Qing Zhang, Yan Liu, Department of Gastroenterology, The 909th Hospital, School of Medicine, Xiamen University, Zhangzhou 363000, Fujian Province, China
Co-first authors: Pei Li and Rong-Rong Ding.
Author contributions: Li P organized the case and wrote manuscript; Ding RR contributed to administered therapy for patient and wrote manuscript; Liu J contributed to supervised writing of manuscript; Zhang MQ contributed to performed surgical procedures for patient; Liu Y contributed to drafting the manuscript.
Supported by Natural Science Foundation of Fujian Province, China, No. 2021J01545.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Liu, Research Fellow, Department of Gastroenterology, The 909th Hospital, School of Medicine, Xiamen University, No. 269 Zhanghua Middle Road, Zhangzhou 363000, Fujian Province, China. 514461566@qq.com
Received: May 12, 2025 Revised: May 30, 2025 Accepted: June 27, 2025 Published online: August 16, 2025 Processing time: 97 Days and 18.3 Hours
Abstract
BACKGROUND
Secure transluminal closure remains a fundamental barrier to endoscopic surgery. It has been reported that through-the-scope clips were used to secure the incision of the gallbladder during natural orifice transluminal endoscopic cholecystolithotomy and were left in the body post-operation. The over-the-scope clip (OTSC) is favored for its rapid deployment and strong anchoring capabilities. Nevertheless, OTSCs are difficult to remove once implanted. The Senscure Biotechnology in China has developed a detachable over-the-scope clip (D-OTSC) for this purpose. Here, we utilized the D-OTSC to successfully close a full-thickness sigmoid defect exceeding 1 cm in diameter. Subsequently, the clip was completely removed postoperatively, yielding favorable clinical outcomes.
CASE SUMMARY
We present the case of a 51-year-old female patient who underwent natural orifice transluminal endoscopic cholecystolithotomy. The sigmoid incision was closed using a D-OTSC. Postoperative recovery was uneventful, with no abdominal infection or bleeding. The D-OTSC was subsequently removed via enteroscopy in the outpatient department one month later.
CONCLUSION
The utilization of D-OTSC presents a viable option for closing colonic mucosal incisions ranging from 1 cm to 2 cm.
Core Tip: In response to clinical requirements, ongoing efforts are being made to investigate the utilization of anastomotic or metal clips for the closure of various full-thickness defects in the mucosa of the digestive tract. Here, we present the case of a 51-year-old patient who underwent transintestinal natural orifice transluminal endoscopic cholecystolithotomy. The sigmoid incision was sealed using a detachable over-the-scope clip (D-OTSC), which was subsequently extracted during enteroscopy one month postoperatively. We believe that the D-OTSC is a viable option for closing colon defects ranging from 1 cm to 2 cm.
