Evaluating cirrhosis and respiratory syncytial virus infection: Should we vaccinate?

Table 1 Characteristics of patients hospitalised with respiratory syncytial virus, n (%)/median (interquartile range)

Characteristics	n = 163
Age, years	75 (67-84)
Sex, female	99 (60.7)
Duration of hospitalization, days	4.7 (2.5-8.4)
Chronic health condition
Cirrhosis	2 (1.2)
Ischaemic heart disease	10 (6.1)
Congestive heart failure	29 (17.8)
COPD	24 (14.7)
Chronic kidney disease	17 (10.4)
Obesity	0 (0.0)
Diabetes	63 (38.7)
Number of chronic health conditions
0	54
1	82
2	19
3	7
4	1

COPD: Chronic obstructive pulmonary disease.

Table 2 Chronic health conditions assessed and incidence of respiratory syncytial virus (n = 49758), n (%)/median (interquartile range)

	n	Age	Female	RSV+ (n)	RSV+ (%)
Cirrhosis	744	53 (63-73)	229 (30.8)	2	0.3
Ischaemic heart disease	7316	53 (64-75)	2534 (34.6)	10	0.1
Congestive heart failure	5551	66 (79-87)	2664 (48.0)	29	0.5
COPD	3246	64 (74-82)	1551 (47.8)	24	0.7
Chronic kidney disease	2590	71 (81-88)	1314 (50.7)	17	0.7
Obesity	1089	28 (22-39)	983 (90.3)	0	0
Diabetes	33602	57 (68-78)	15536 (46.2)	63	0.2

RSV: Respiratory syncytial virus; COPD: Chronic obstructive pulmonary disease.

Table 3 Characteristics of patients hospitalised with and without respiratory syncytial virus, n (%)/median (interquartile range)

	RSV+	RSV-	P value
Age, years	78 (71-85)	68 (56-79)	< 0.001
Sex (female)	58 (53.2)	22879 (46.1)	0.163
Cirrhosis	2 (1.8)	742 (1.5)	1.000
Ischaemic heart disease	10 (9.2)	7306 (14.7)	0.135
Congestive heart failure	29 (26.6)	5522 (11.1)	< 0.001
COPD	24 (22.0)	3222 (6.5)	< 0.001
Chronic kidney disease	17 (15.6)	2573 (5.2)	< 0.001
Obesity	0 (0.0)	1089 (2.2)	0.217
Diabetes	63 (57.8)	33539 (67.6)	0.039

From a cohort of patients with specific chronic health conditions (n = 49758), 109 with respiratory syncytial virus. RSV: Respiratory syncytial virus; COPD: Chronic obstructive pulmonary disease.

Table 4 Multivariable logistic regression: Independent risk factors for mortality in patients hospitalised with respiratory syncytial virus

Variable	Adjusted OR	95% confidence interval	P value
Age (years)	1.05	1.02-1.09	0.002
Sex (female)	1.01	0.48-2.16	0.980
Cirrhosis	8.56	0.3-245.53	0.154
Ischaemic heart disease	1.72	0.38-7.32	0.460
Congestive heart failure	0.9	0.3-2.63	0.853
COPD	0.72	0.2-2.29	0.588
Chronic kidney disease	2.02	0.63-6.44	0.229
Diabetes	2.19	1.01-4.84	0.049

OR: Odds ratio; COPD: Chronic obstructive pulmonary disease.