Functional cure in an occult hepatitis B virus infection patient on sequential therapy: A case report

Table 1 Evolution of hepatitis B pentameter and liver function during the treatment of patients with chronic hepatitis B

Weeks		Treatment regimen	HBV-DNA (IU/mL)	HBsAg (0-0.05 IU/mL)	HBsAb (0-10 mIU/mL)	HBeAg (0-0.18 PEIU/mL)	HBeAb (1-999 S/CO)	HBcAb (0-1 S/CO)	ALT (0-40 U/L)	AST (0-40 U/L)	GGT (0-58 U/L)	CAP (< 238 dB/m)	LSM (2.5-7kPa)	AST/ALT
0		ETV	< 251	29.93	0.029	0.029	1.093	0.029	29	37	35	269	6.3	1.28
4		ETV + PEG	—	445.65	0.68	0.11	1.14	8.94	71	75	53	-	-	1.06
8		ETV + PEG	—	337.45	0.24	0.09	1.13	8.75	216	217	95	-	-	1.00
12		ETV + PEG	8.0E + 011	49.48	0.31	0.11	1.16	8.92	126	129	105	-	-	1.02
16		ETV + PEG	1.40E + 021	5.47	0.28	0.1	1.15	8.03	109	116	113	230	7.1	1.06
33		ETV + PEG	1.73E + 021	0.42	1.96	0.11	1.1	6.99	122	119	120	278	7.9	0.98
48		ETV + PEG	1.77E + 022	0.06	6	0.11	1.13	9.37	61	73	86	294	11.7	1.19
OBI phase	61	ETV + PEG	3.70E + 012	0.01	52.18	0.14	1.2	8.55	91	101	119	-	-	1.11
	72	ETV + PEG	9.20E + 012	0.01	142.41	0.14	1.3	9.32	98	119	117	253	9.8	1.21
	82	PEG	1.90E + 012	0	134.59	0.14	1.55	8.44	122	157	112	-	-	1.29
	91	PEG	1.10E + 012	0.01	82.28	0.13	1.3	7.12	73	90	119	-	-	1.23
	101	PEG	< 102	0.02	49.55	0.15	1.32	7.51	65	80	94	-	-	1.23
	115	PEG	4.10E + 012	0.02	58.37	0.18	1.54	7.53	30	72	120	-	-	2.40
120		D/C PEG for 1 months	< 102	0	89.18	0.22	1.43	7.64	-	-	-	-	-	-
129		D/C PEG for 3 months	< 102	0	91.6	0.16	1.36	6.37	26	29	34	-	-	1.12
140		D/C PEG for 6 months	< 102	0	112.26	0.14	1.32	8.73	23	25	33	-	-	1.09
154		D/C PEG for 9 months	-	0	123.62	0.16	1.34	7.05	18	26	28	-	-	1.44
174		D/C PEG for 13 months	< 102	0	44.04	0.15	1.42	6.49	20	26	26	176	7	1.30
188		D/C PEG for 17 months	< 102	0.03	30.84	0.18	1.46	6.61	20	30	30	-	-	1.60
212		D/C PEG for 23 months	< 251	0	8.11	0.17	1.02	6.31	20	29	30	239	5.9	1.45

¹Standard hepatitis B virus DNA assay: The lower limit of detection is 25 IU/mL.

²High-sensitivity hepatitis B virus DNA assay: The lower limit of detection is 10 IU/mL.

Detection method for hepatitis B serology panel - electrochemiluminescence immunoassay. HBV: Hepatitis B virus; HBsAb: Hepatitis B surface antibody; HBeAg: Hepatitis B e antigen; HBeAb: Hepatitis B e antibody; HBcAb: Hepatitis B core antibody; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Glutamyltransferase; CAP: Controlled attenuation parameter; LSM: Liver stiffness measurements; ETV: Entecavir; PEG: Pegylated; D/C: Discontinued; OBI: Occult hepatitis B virus infection; S/CO: Signal-to-cutoff ratio.