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©The Author(s) 2025.
World J Hepatol. Oct 27, 2025; 17(10): 109583
Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.109583
Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.109583
Table 1 Demographics and clinical characteristics, n (%)
| Characteristic | Patient total (n = 52) |
| Age | |
| N (missing) | 52 (0) |
| Median (IQR) | 45.0 (35.5, 51.5) |
| Sex | |
| Female | 26 (50.0) |
| Male | 26 (50.0) |
| Ethnicity | |
| African | 1 (1.9) |
| African American | 6 (11.5) |
| Caucasian | 31 (59.6) |
| Hispanic | 11 (21.2) |
| Native American | 1 (1.9) |
| Other | 2 (3.8) |
| Insurance | |
| Medicaid | 8 (15.4) |
| Medicare | 12 (23.1) |
| None | 8 (15.4) |
| Private | 19 (36.5) |
| Self-pay | 5 (9.6) |
| Marital status | |
| Not married | 41 (78.8) |
| Married | 11 (21.2) |
| Liver disease | |
| Alcohol hepatitis | 22 (42.3) |
| Cirrhosis | 21 (40.4) |
| Steatosis | 9 (17.3) |
| MELD-Na | |
| N (missing) | 46 (6) |
| Median (IQR) | 15.5 (10.0, 25.0) |
| Hepatic encephalopathy | |
| No | 45 (86.5) |
| Yes | 7 (13.5) |
| Ascites | |
| No | 30 (57.7) |
| Yes | 22 (42.3) |
| Esophageal varices | |
| No | 40 (76.9) |
| Yes | 12 (23.1) |
| Hepatocellular carcinoma | |
| No | 52 (100.0) |
| Self-reported drinks | |
| N (missing) | 52 (0) |
| Median (IQR) | 8.0 (3.0, 22.0) |
| Ethanol | |
| N (missing) | 48 (4) |
| Median (IQR) | 71.0 (0.0, 224.0) |
| Phosphatidylethanol (pETH) | |
| N (missing) | 26 (26) |
| Median (IQR) | 356.5 (51.0, 917.0) |
| Withdrawal | |
| No | 21 (40.4) |
| Yes | 31 (59.6) |
| Previous pharmacologic treatment | |
| No | 38 (73.1) |
| Yes | 14 (26.9) |
| Acamprosate | |
| No | 49 (94.2) |
| Yes | 3 (5.8) |
| Disulfiram | |
| No | 52 (100.0) |
| Naltrexone | |
| No | 42 (80.8) |
| Yes | 10 (19.2) |
| Vivitrol | |
| No | 42 (80.8) |
| Yes | 10 (19.2) |
| Previous behavioral treatment | |
| No | 33 (63.5) |
| Yes | 19 (36.5) |
| Inpatient treatment | |
| No | 44 (84.6) |
| Yes | 8 (15.4) |
| Outpatient treatment | |
| No | 44 (84.6) |
| Yes | 8 (15.4) |
| Mutual aid | |
| No | 37 (71.2) |
| Yes | 15 (28.8) |
| Behavioral and pharmacologic treatment | |
| No | 46 (88.5) |
| Yes | 6 (11.5) |
| Seen by addiction psychiatry | |
| No | 16 (30.8) |
| Yes | 36 (69.2) |
| Seen by GI | |
| No | 17 (32.7) |
| Yes | 35 (67.3) |
Table 2 Treatment education for alcohol misuse cohort outcomes by treatment type, n (%)
| Outcome variable | Treatment group | Total (n = 42) | P value1 | ||||
| No treatment none (n = 6) | Treatment | ||||||
| Pharmacologic (n = 21) | Behavioral (n = 31) | Both (n = 17) | Any treatment (n = 36) | ||||
| 30-day follow-up | 1.0012 | ||||||
| Attempted, unsuccessful | 0 (0.0) | 2 (9.5) | 0 (0.0) | 0 (0.0) | 2 (5.7) | 2 (4.9) | |
| Successful | 6 (100.0) | 19 (90.5) | 30 (100.0) | 17 (100.0) | 33 (94.3) | 39 (95.1) | |
| Missing | 0 | 0 | 1 | 0 | 1 | 1 | |
| Recall drinks | 0.8623 | ||||||
| N (missing) | 6 (0) | 18 (3) | 28 (3) | 16 (1) | 31 (5) | 37 (5) | |
| Median (IQR) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | |
| Ethanol | |||||||
| N (missing) | 2 (4) | 9 (12) | 12 (19) | 7 (10) | 14 (22) | 16 (26) | - |
| Median (IQR) | 103.0 (0.0, 206.0) | 0.0 (0.0, 162.0) | 0.0 (0.0, 81.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 162.0) | 0.0 (0.0, 174.0) | - |
| Phosphatidylethanol (pETH) | |||||||
| N (missing) | 1 (5) | 3 (18) | 9 (22) | 3 (14) | 9 (27) | 10 (32) | - |
| Median (IQR) | 14.0 (14.0, 14.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 14.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 14.0) | - |
| Outpatient follow-up visit | 0.3712 | ||||||
| No | 5 (83.3) | 10 (50.0) | 14 (50.0) | 6 (37.5) | 18 (54.5) | 23 (59.0) | |
| Yes | 1 (16.7) | 10 (50.0) | 14 (50.0) | 10 (62.5) | 15 (45.5) | 16 (41.0) | |
| Missing | 0 | 1 | 3 | 1 | 3 | 3 | |
| 30-day readmission | 1.0012 | ||||||
| No | 4 (66.7) | 14 (66.7) | 21 (67.7) | 12 (70.6) | 25 (69.4) | 29 (69.0) | |
| Yes | 2 (33.3) | 7 (33.3) | 10 (32.3) | 5 (29.4) | 11 (30.6) | 13 (31.0) | |
| 30-day mortality | 1.0012 | ||||||
| No | 6 (100.0) | 21 (100.0) | 29 (93.5) | 17 (100.0) | 34 (94.4) | 40 (95.2) | |
| Yes | 0 (0.0) | 0 (0.0) | 2 (6.5) | 0 (0.0) | 2 (5.6) | 2 (4.8) | |
| 30-day relapse | 0.4112 | ||||||
| No | 5 (83.3) | 17 (89.5) | 27 (93.1) | 16 (94.1) | 30 (93.8) | 35 (92.1) | |
| Yes | 1 (16.7) | 2 (10.5) | 2 (6.9) | 1 (5.9) | 2 (6.3) | 3 (7.9) | |
| Missing | 0 | 2 | 2 | 0 | 4 | 4 | |
| Found the module helpful | 0.3912 | ||||||
| No | 1 (16.7) | 1 (5.3) | 2 (6.5) | 1 (5.9) | 2 (5.9) | 3 (7.5) | |
| Yes | 5 (83.3) | 18 (94.7) | 29 (93.5) | 16 (94.1) | 32 (94.1) | 37 (92.5) | |
| Missing | 0 | 2 | 0 | 0 | 2 | 2 | |
| Recommend the module | |||||||
| Yes | 6 (100.0) | 19 (100.0) | 31 (100.0) | 17 (100.0) | 34 (100.0) | 40 (100.0) | - |
| Missing | 0 | 2 | 0 | 0 | 2 | 2 | - |
Table 3 Treatment rates and disease-related variables before and after the educational video module, n (%)
| Treatment | Group | P value | |
| Pre-intervention (n = 43) | Post-intervention (n = 43) | ||
| Pharmacy treatment | 0.021 | ||
| No | 31 (72.1) | 22 (51.2) | |
| Yes | 12 (27.9) | 21 (48.8) | |
| Missing | 0 | 0 | |
| Acamprosate | 0.481 | ||
| No | 40 (93.0) | 38 (88.4) | |
| Yes | 3 (7.0) | 5 (11.6) | |
| Missing | 0 | 0 | |
| Disulfiram | |||
| No | 43 (100) | 43 (100) | - |
| Missing | 0 | 0 | - |
| Naltrexone | 0.201 | ||
| No | 34 (79.1) | 29 (67.4) | |
| Yes | 9 (20.9) | 14 (32.6) | |
| Missing | 0 | 0 | |
| Vivitrol | 0.171 | ||
| No | 34 (79.1) | 29 (67.4) | |
| Yes | 9 (20.9) | 14 (32.6) | |
| Missing | 0 | 0 | |
| Behavioral treatment | 0.0031 | ||
| No | 27 (62.8) | 12 (27.9) | |
| Yes | 16 (37.2) | 31 (72.1) | |
| Missing | 0 | 0 | |
| Inpatient treatment | 0.261 | ||
| No | 36 (83.7) | 39 (90.7) | |
| Yes | 7 (16.3) | 4 (9.3) | |
| Missing | 0 | 0 | |
| Outpatient treatment | 0.00021 | ||
| No | 39 (90.7) | 23 (53.5) | |
| Yes | 4 (9.3) | 20 (46.5) | |
| Missing | 0 | 0 | |
| Mutual aid | 0.101 | ||
| No | 28 (66.7) | 20 (47.6) | |
| Yes | 14 (33.3) | 22 (52.4) | |
| Missing | 1 | 1 | |
| Behavioral and pharmacologictreatment | 0.0071 | ||
| No | 37 (88.1) | 25 (59.5) | |
| Yes | 5 (11.9) | 17 (40.5) | |
| Missing | 1 | 1 | |
- Citation: Twohig P, Slocum ZP, Willet A, Schissel M, Balasanova AA, Scholten K, Warner J, Sempokuya T, Khoury N, Ashford A, Peeraphatdit TB. Novel educational video module about alcohol use disorder increases treatment rates and decreases return to alcohol use. World J Hepatol 2025; 17(10): 109583
- URL: https://www.wjgnet.com/1948-5182/full/v17/i10/109583.htm
- DOI: https://dx.doi.org/10.4254/wjh.v17.i10.109583
