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Observational Study
Copyright ©The Author(s) 2025.
World J Hepatol. Oct 27, 2025; 17(10): 109583
Published online Oct 27, 2025. doi: 10.4254/wjh.v17.i10.109583
Table 1 Demographics and clinical characteristics, n (%)
CharacteristicPatient total (n = 52)
Age
N (missing)52 (0)
Median (IQR)45.0 (35.5, 51.5)
Sex
Female26 (50.0)
Male26 (50.0)
Ethnicity
African1 (1.9)
African American6 (11.5)
Caucasian31 (59.6)
Hispanic11 (21.2)
Native American1 (1.9)
Other2 (3.8)
Insurance
Medicaid8 (15.4)
Medicare12 (23.1)
None8 (15.4)
Private19 (36.5)
Self-pay5 (9.6)
Marital status
Not married41 (78.8)
Married11 (21.2)
Liver disease
Alcohol hepatitis22 (42.3)
Cirrhosis21 (40.4)
Steatosis9 (17.3)
MELD-Na
N (missing)46 (6)
Median (IQR)15.5 (10.0, 25.0)
Hepatic encephalopathy
No45 (86.5)
Yes7 (13.5)
Ascites
No30 (57.7)
Yes22 (42.3)
Esophageal varices
No40 (76.9)
Yes12 (23.1)
Hepatocellular carcinoma
No52 (100.0)
Self-reported drinks
N (missing)52 (0)
Median (IQR)8.0 (3.0, 22.0)
Ethanol
N (missing)48 (4)
Median (IQR)71.0 (0.0, 224.0)
Phosphatidylethanol (pETH)
N (missing)26 (26)
Median (IQR)356.5 (51.0, 917.0)
Withdrawal
No21 (40.4)
Yes31 (59.6)
Previous pharmacologic treatment
No38 (73.1)
Yes14 (26.9)
Acamprosate
No49 (94.2)
Yes3 (5.8)
Disulfiram
No52 (100.0)
Naltrexone
No42 (80.8)
Yes10 (19.2)
Vivitrol
No42 (80.8)
Yes10 (19.2)
Previous behavioral treatment
No33 (63.5)
Yes19 (36.5)
Inpatient treatment
No44 (84.6)
Yes8 (15.4)
Outpatient treatment
No44 (84.6)
Yes8 (15.4)
Mutual aid
No37 (71.2)
Yes15 (28.8)
Behavioral and pharmacologic treatment
No46 (88.5)
Yes6 (11.5)
Seen by addiction psychiatry
No16 (30.8)
Yes36 (69.2)
Seen by GI
No17 (32.7)
Yes35 (67.3)
Table 2 Treatment education for alcohol misuse cohort outcomes by treatment type, n (%)
Outcome variable
Treatment group
Total (n = 42)P value1
No treatment none (n = 6)Treatment
Pharmacologic (n = 21)
Behavioral (n = 31)
Both (n = 17)
Any treatment (n = 36)
30-day follow-up1.0012
Attempted, unsuccessful0 (0.0)2 (9.5)0 (0.0)0 (0.0)2 (5.7)2 (4.9)
Successful6 (100.0)19 (90.5)30 (100.0)17 (100.0)33 (94.3)39 (95.1)
Missing001011
Recall drinks0.8623
N (missing)6 (0)18 (3)28 (3)16 (1)31 (5)37 (5)
Median (IQR)0.0 (0.0, 0.0)0.0 (0.0, 0.0)0.0 (0.0, 0.0)0.0 (0.0, 0.0)0.0 (0.0, 0.0)0.0 (0.0, 0.0)
Ethanol
N (missing)2 (4)9 (12)12 (19)7 (10)14 (22)16 (26)-
Median (IQR)103.0 (0.0, 206.0)0.0 (0.0, 162.0)0.0 (0.0, 81.0)0.0 (0.0, 0.0)0.0 (0.0, 162.0)0.0 (0.0, 174.0)-
Phosphatidylethanol (pETH)
N (missing)1 (5)3 (18)9 (22)3 (14)9 (27)10 (32)-
Median (IQR)14.0 (14.0, 14.0)0.0 (0.0, 0.0)0.0 (0.0, 14.0)0.0 (0.0, 0.0)0.0 (0.0, 0.0)0.0 (0.0, 14.0)-
Outpatient follow-up visit0.3712
No5 (83.3)10 (50.0)14 (50.0)6 (37.5)18 (54.5)23 (59.0)
Yes1 (16.7)10 (50.0)14 (50.0)10 (62.5)15 (45.5)16 (41.0)
Missing013133
30-day readmission1.0012
No4 (66.7)14 (66.7)21 (67.7)12 (70.6)25 (69.4)29 (69.0)
Yes2 (33.3)7 (33.3)10 (32.3)5 (29.4)11 (30.6)13 (31.0)
30-day mortality1.0012
No6 (100.0)21 (100.0)29 (93.5)17 (100.0)34 (94.4)40 (95.2)
Yes0 (0.0)0 (0.0)2 (6.5)0 (0.0)2 (5.6)2 (4.8)
30-day relapse0.4112
No5 (83.3)17 (89.5)27 (93.1)16 (94.1)30 (93.8)35 (92.1)
Yes1 (16.7)2 (10.5)2 (6.9)1 (5.9)2 (6.3)3 (7.9)
Missing022044
Found the module helpful0.3912
No1 (16.7)1 (5.3)2 (6.5)1 (5.9)2 (5.9)3 (7.5)
Yes5 (83.3)18 (94.7)29 (93.5)16 (94.1)32 (94.1)37 (92.5)
Missing020022
Recommend the module
Yes6 (100.0)19 (100.0)31 (100.0)17 (100.0)34 (100.0)40 (100.0)-
Missing020022-
Table 3 Treatment rates and disease-related variables before and after the educational video module, n (%)
TreatmentGroup
P value
Pre-intervention (n = 43)
Post-intervention (n = 43)
Pharmacy treatment0.021
No31 (72.1)22 (51.2)
Yes12 (27.9)21 (48.8)
Missing00
Acamprosate0.481
No40 (93.0)38 (88.4)
Yes3 (7.0)5 (11.6)
Missing00
Disulfiram
No43 (100)43 (100)-
Missing00-
Naltrexone0.201
No34 (79.1)29 (67.4)
Yes9 (20.9)14 (32.6)
Missing00
Vivitrol0.171
No34 (79.1)29 (67.4)
Yes9 (20.9)14 (32.6)
Missing00
Behavioral treatment0.0031
No27 (62.8)12 (27.9)
Yes16 (37.2)31 (72.1)
Missing00
Inpatient treatment0.261
No36 (83.7)39 (90.7)
Yes7 (16.3)4 (9.3)
Missing00
Outpatient treatment0.00021
No39 (90.7)23 (53.5)
Yes4 (9.3)20 (46.5)
Missing00
Mutual aid0.101
No28 (66.7)20 (47.6)
Yes14 (33.3)22 (52.4)
Missing11
Behavioral and pharmacologictreatment0.0071
No37 (88.1)25 (59.5)
Yes5 (11.9)17 (40.5)
Missing11