Clinical and Translational Research
Copyright ©The Author(s) 2024.
World J Hepatol. Aug 27, 2024; 16(8): 1156-1166
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1156
Table 1 Number of single-nucleotide polymorphisms screened in each step
ID exposure
Panel
Immune traits
Number of SNPs after LD
Number of SNPs after F > 10
Number of final IVs
Ebi-a-GCST90001433B cellIgD- CD27-% lymphocyte181818
Ebi-a-GCST90001706B cellBAFF-R on IgD + CD38- naive292928
Ebi-a-GCST90001762B cellCD20 on IgD +232319
Ebi-a-GCST90001790B cellCD25 on memory B cell272724
Ebi-a-GCST90001830B cellBAFF-R on CD20-141414
Ebi-a-GCST90001793B cellCD25 on sw mem212120
Ebi-a-GCST90001809B cellCD38 on CD20-202019
Ebi-a-GCST90002110Myeloid cellHLA DR on CD33dim HLA DR + CD11b +242423
Ebi-a-GCST90001954Myeloid cellCD33 on basophil232322
Ebi-a-GCST90001952Myeloid cellCD33 on Mo MDSC212121
Ebi-a-GCST90001951Myeloid cellCD33 on CD66b + + myeloid cell191918
Ebi-a-GCST90001521Myeloid cellCD33 bright HLA DR + CD14 dim% CD33 bright HLA DR +262625
Ebi-a-GCST90001953Myeloid cellCD33 on CD33 dim HLA DR-212119
Ebi-a-GCST90001955Myeloid cellCD33 on Im MDSC252522
Ebi-a-GCST90002031TregCD39 on CD39 + secreting Treg242423
Ebi-a-GCST90001901TregCD28 on CD39 + resting Treg232322
Ebi-a-GCST90001688TregCD28 + CD45 RA + CD8 bright% T cell1129188
Ebi-a-GCST90001630TBNKCD8 bright NKT AC272726
Ebi-a-GCST90002076TBNKSSC-A on NK242423
Ebi-a-GCST90002014cDCCCR2 on CD62L++ myeloid DC151514
Table 2 Forward mendelian randomization sensitivity analysis
Exposure panel
Exposure traits
Inverse variance weighted
MR-Egger
Q value
P value
Intercept
P value
B cellIgD- CD27-% lymphocyte11.200.8460.0080.707
B cellBAFF-R on IgD+ CD38- naive19.980.8310.0020.880
B cellCD20 on IgD+18.760.407-0.0040.662
B cellCD25 on memory B cell21.520.549-0.0020.854
B cellBAFF-R on CD20-9.740.715-0.0050.795
B cellCD25 on sw mem17.720.5410.0040.771
B cellCD38 on CD20-14.730.6800.0120.521
Myeloid cellHLA DR on CD33dim HLA DR+ CD11b+25.660.266-0.0110.303
Myeloid cellCD33 on basophil29.560.1010.0140.248
Myeloid cellCD33 on Mo MDSC23.260.276-0.0070.490
Myeloid cellCD33 on CD66b+ myeloid cell18.200.376-0.0290.065
Myeloid cellCD33 bright HLA DR+ CD14 dim% CD33 bright HLA DR+29.630.1970.0110.294
Myeloid cellCD33 on CD33 dim HLA DR-18.450.4270.0180.184
Myeloid cellCD33 on Im MDSC30.800.0770.0130.354
TregCD39 on CD39+ secreting Treg10.760.978-0.0050.554
TregCD28 on CD39+ resting Treg21.590.4230.0130.220
TregCD28+ CD45 RA+ CD8 bright% T cell80.460.6760.0090.252
TBNKCD8 bright NKT AC25.190.452-0.0140.225
TBNKSSC-A on NK27.350.1980.0040.771
cDCCCR2 on CD62L+ myeloid DC9.060.7680.0110.547
Table 3 Number of Single-nucleotide polymorphisms screened in each step
ID exposure
Number of SNPs after LD
Number of SNPs after F > 10
Number of final IVs
Finn-b-CIRRHOSIS_BROAD313131
Table 4 Reverse mendelian randomization sensitivity analysis
Outcome panel
Outcome traits
Inverse variance weighted
MR-Egger
Q value
P value
intercept
P value
B cellIgD+ CD38 bright AC35.510.224-0.0140.401
B cellIgD+ CD38 dim AC30.730.429-0.0300.068
B cellIgD+ AC33.150.316-0.0280.094
B cellNaive-mature B cell AC27.470.599-0.0220.160
B cellIgD+ CD24- AC29.820.475-0.0190.250
cDCCD62L- plasmacytoid DC AC29.390.4970.0290.075
Myeloid cellIm MDSC AC29.230.5060.0190.249
Myeloid cellIm MDSC% CD33 dim HLA DR- CD66b-24.090.7680.0090.568
Myeloid cellCD33- HLA DR+ AC30.390.446-0.0040.790
TBNKCD4+% leukocyte16.120.9820.0070.670
TBNKCD3- lymphocyte% leukocyte17.100.9710.0130.443
TregCD28+ CD45RA- CD8 dim AC37.390.1660.0000.997
B cellCD20 on CD24+ CD27+22.520.8340.0260.231
B cellCD20 on sw mem32.590.3410.0200.381
TBNKFSC-A on B cell25.610.6950.0170.345
MonocyteCX3CR1 on monocyte39.690.1110.0020.891
MonocyteCX3CR1 on CD14- CD16+ monocyte19.800.9220.0080.641
TBNKSSC-A on B cell32.700.336-0.0030.844
TregCD8 on CD28- CD8 bright37.590.106-0.0030.877