©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 27, 2024; 16(8): 1156-1166
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1156
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1156
Causal association between 731 immunocyte phenotypes and liver cirrhosis: A bidirectional two-sample mendelian randomization analysis
Ying Li, Xin Quan, Yang Tai, Bo Wei, Hao Wu, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Yu-Tong Wu, Department of Clinical Medicine, Chongqing Medical University, Chongqing 400016, China
Co-first authors: Ying Li and Xin Quan.
Author contributions: Li Y and Quan X designed the study, reviewed the literature, and wrote the manuscript; Tai Y and Wu YT performed the data analyses; Wei B downloaded the data from the genome-wide association studies database, and Wu H participated in the drafting and editing of the manuscript; All the authors have read and approved the final manuscript for submission.
Supported by the National Natural Science Foundation of China , No. 82270649 .
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Hao Wu, PhD, Doctor, Professor, Department of Gastroenterology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, China. hxxhwh@163.com
Received: June 2, 2024
Revised: July 24, 2024
Accepted: August 2, 2024
Published online: August 27, 2024
Processing time: 81 Days and 15.8 Hours
Revised: July 24, 2024
Accepted: August 2, 2024
Published online: August 27, 2024
Processing time: 81 Days and 15.8 Hours
Core Tip
Core Tip: The causal relationship between immunocyte phenotypes and liver cirrhosis has not been fully elucidated. This bidirectional two-sample mendelian randomization study identified a significant causal association between 731 immunocyte phenotypes and liver cirrhosis. We found that 20 immunocyte phenotypes were associated with liver cirrhosis (P < 0.05), whereas liver cirrhosis was associated with 19 immunocyte phenotypes (P < 0.05). None of these associations showed heterogeneity or horizontal pleiotropy (P > 0.05). These findings provide novel directions for the treatment of liver cirrhosis.