Torres-Valadez R, Roman S, Ojeda-Granados C, Gonzalez-Aldaco K, Panduro A. Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans. World J Hepatol 2022; 14(7): 1408-1420 [PMID: 36158920 DOI: 10.4254/wjh.v14.i7.1408]
Corresponding Author of This Article
Arturo Panduro, FAASLD, MD, PhD, Research Scientist, Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara Fray Antonio Alcalde/Health Sciences Center, University of Guadalajara, Hospital # 278 Col. El Retiro, Guadalajara, Jalisco 44280, Mexico. apanduro@prodigy.net.mx
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 6 Association of APOB and LDLR genotypes with hypercholesterolemia in normal weight Mestizos individuals
Genotype
Non-HChol
HChol
P value
Genotype comparison
Odds ratio (95%CI)
P value
APOB -516C/T genotypes
CC
76 (58.0%)
9 (39.1%)
0.120
TT vs CC
5.33 (1.537-18.502)
0.008
CT
46 (35.1%)
8 (34.8%)
0.895
TT vs CC + CT
4.63 (1.463-14.634)
0.009
TT
9 (6.9%)
6 (26.1%)
0.005
TT vs CT
3.83 (1.069-13.746)
0.039
LDLR A1413G genotypes
AA
21 (16.5%)
1 (4.3%)
0.135
GG vs AA
3.90 (1.042-14.583)
0.043
AG
57 (44.9%)
8 (34.8%)
0.340
GG vs AA + AG
2.53 (1.216-5.282)
0.013
GG
49 (38.6%)
14 (60.9%)
0.043
GG vs AG
2.24 (1.028-4.890)
0.042
Table 7 Increased serum level of low-density lipoprotein cholesterol associated with APOB and LDLR genotypes in individuals with normal weight from West Mexico
Genotype comparison
R2
β
95%CI
P value
APOB -516C/T
TT vs CC
0.30
40.39
14.415-66.366
0.004
TT vs CC + CT
0.23
39.79
16.226-63.363
0.001
TT vs CT
0.31
39.01
0.996-67.029
0.091
LDLR A1413G
GG vs AA
0.11
23.29
1.640-44.946
0.036
GG vs AA + AG
0.11
20.77
5.763-35.784
0.007
GG vs AG
0.08
19.74
0.915-37.270
0.082
Citation: Torres-Valadez R, Roman S, Ojeda-Granados C, Gonzalez-Aldaco K, Panduro A. Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans. World J Hepatol 2022; 14(7): 1408-1420