Torres-Valadez R, Roman S, Ojeda-Granados C, Gonzalez-Aldaco K, Panduro A. Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans. World J Hepatol 2022; 14(7): 1408-1420 [PMID: 36158920 DOI: 10.4254/wjh.v14.i7.1408]
Corresponding Author of This Article
Arturo Panduro, FAASLD, MD, PhD, Research Scientist, Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara Fray Antonio Alcalde/Health Sciences Center, University of Guadalajara, Hospital # 278 Col. El Retiro, Guadalajara, Jalisco 44280, Mexico. apanduro@prodigy.net.mx
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Jul 27, 2022; 14(7): 1408-1420 Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1408
Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans
Rafael Torres-Valadez, Sonia Roman, Claudia Ojeda-Granados, Karina Gonzalez-Aldaco, Arturo Panduro
Rafael Torres-Valadez, Sonia Roman, Claudia Ojeda-Granados, Karina Gonzalez-Aldaco, Arturo Panduro, Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara Fray Antonio Alcalde/Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44280, Mexico
Rafael Torres-Valadez, Unidad Especializada en Investigación, Desarrollo e Innovación en Medicina Genómica Centro Nayarita de Innovación y Transferencia de Tecnología, Universidad Autónoma de Nayarit, Unidad Académica de Salud Integral, Tepic, Nayarit 63173, Mexico
Author contributions: Panduro A conceived and designed the study; Torres-Valadez R, Ojeda-Granados C and Gonzalez-Aldaco K carried out experimentation, and data collection; Panduro A, Torres-Valadez R, Roman S, Ojeda-Granados C, Gonzalez-Aldaco K did analyses and interpretation of data; Torres-Valadez R drafted the manuscript. All authors critically revised the manuscript for intellectual content. All authors revised and approved the final version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the Civil Hospital of Guadalajara, Guadalajara, Jalisco, Mexico.
Informed consent statement: All patients signed a written informed consent before enrollment, and anonymized data was employed to continue the statistical analysis.
Conflict-of-interest statement: All authors have no conflict of interest to disclose.
Data sharing statement: The dataset is available from the corresponding author at apanduro@prodigy.net.mx.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arturo Panduro, FAASLD, MD, PhD, Research Scientist, Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara Fray Antonio Alcalde/Health Sciences Center, University of Guadalajara, Hospital # 278 Col. El Retiro, Guadalajara, Jalisco 44280, Mexico. apanduro@prodigy.net.mx
Received: January 21, 2022 Peer-review started: January 21, 2022 First decision: June 7, 2022 Revised: June 20, 2022 Accepted: July 6, 2022 Article in press: July 6, 2022 Published online: July 27, 2022 Processing time: 187 Days and 12.3 Hours
ARTICLE HIGHLIGHTS
Research background
Further investigations are needed to provide medical and nutritional therapies based on the genetic background of the population and the role of lifestyle changes including diet, exercise and mental health.
Research motivation
Given the differential distribution of gene polymorphisms and rate of dyslipidemias found in this study, primary health care strategies are required to establish preventive actions to mitigate their prevalence considering the regional genetic and cultural differences, which could have important implications for personalized medicine within the new era of precision medicine.
Research objectives
We aimed to describe if there are important differences between Native American and Mestizo Mexicans in regard to the type of dyslipidemias and lipid-related genetic polymorphisms.
Research methods
In this retrospective study, 1324 adults were selected to compare dyslipidemias and lipid-related gene polymorphisms. Demographic, clinical, and laboratory data were collected. A subgroup of 196 normal weight Mestizo subjects without impaired glucose was selected for the association analyses. Genotyping was determined by allelic discrimination assay.
Research results
The Native Americans showed a greater genetic susceptibility for developing hypercholesterolemia (HChol) (APOE4, LDLR) and hypoalphalipoproteinemia (ABCA1). The TT genotype of APOB -516C/T and GG genotype of LDLR A1413G were associated risk factors for HChol and increased low-density lipoprotein cholesterol levels in Mestizo healthy population.
Research conclusions
Deciphering the role of ethnicity in the type of dyslipidemia and defining the prevalence of lipid-related gene polymorphisms.
Research perspectives
Genetic and environmental factors are involved in the onset and progression of dyslipidemias among the Mexican population.
