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World J Hepatol. Sep 27, 2025; 17(9): 110964
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.110964
Figure 1
Figure 1 Therapeutic potential of melatonin in gallstone disease. Melatonin contributes to gallstone prevention and management through its antioxidant and anti-inflammatory action, cholesterol regulation, improved gallbladder motility, calcium homeostasis restoration, and cellular protection in ageing. Each mechanism is associated with a specific physiological target involved in gallstone pathogenesis.