Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2025; 17(9): 110964
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.110964
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.110964
Melatonin’s anti-inflammatory and antioxidant effects in gallstone disease: A narrative review
Umaimah Batool Mirza, Imteshal Sarfaraz, Zunaira Kiran, Daniyal Sohail, Ahmed Asad Raza, Department of Medicine, Jinnah Sindh Medical University, Karachi 75510, Sindh, Pakistan
Rahim Khan, Department of Emergency Medicine, Shaheed Mohtarma Benazir Bhutto Trauma Unit, Karachi 75510, Sindh, Pakistan
Abedin Samadi, Department of Internal Medicine, Kabul Uni
Author contributions: Batool Mirza U, Sarfaraz I, Kiran Z, Sohail D, Khan R, Raza AA, and Samadi A contributed equally to the development of this manuscript; all authors were involved in conceptualizing key sections, interpreting relevant data, and ensuring the overall quality and accuracy of the content, participated in the literature review, drafting and critical revision, have approved the final manuscript and agree to be accountable for all aspects of the work.
Conflict-of-interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abedin Samadi, MD, Department of Internal Medicine, Kabul Uni
Received: June 19, 2025
Revised: July 23, 2025
Accepted: August 25, 2025
Published online: September 27, 2025
Processing time: 98 Days and 14.6 Hours
Revised: July 23, 2025
Accepted: August 25, 2025
Published online: September 27, 2025
Processing time: 98 Days and 14.6 Hours
Core Tip
Core Tip: Emerging research highlights melatonin as a novel adjunct in gallstone disease management due to its antioxidant, anti-inflammatory, and lipid-regulating properties. Melatonin reduces biliary cholesterol saturation, enhances gallbladder motility, and protects epithelial cells from oxidative stress, addressing key mechanisms of gallstone formation. Its excellent safety profile and potential to prevent recurrence make it a promising non-invasive option, particularly for high-risk or surgery-resistant patients.